Publication Date:
1990-11-23
Description:
Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Phillips, M L -- Nudelman, E -- Gaeta, F C -- Perez, M -- Singhal, A K -- Hakomori, S -- Paulson, J C -- New York, N.Y. -- Science. 1990 Nov 23;250(4984):1130-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cytel Corp., La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1701274" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/pharmacology
;
Antigens, CD15/chemistry/*physiology
;
Carbohydrate Conformation
;
Carbohydrate Sequence
;
Cell Adhesion/*physiology
;
Cell Adhesion Molecules/immunology/*physiology
;
Cell Line
;
Cricetinae
;
E-Selectin
;
Glycosylation
;
Humans
;
Ligands
;
Molecular Sequence Data
;
Neuraminidase/pharmacology
;
Neutrophils/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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