Publication Date:
1983-12-09
Description:
A synthetic heptapeptide from the amino terminus of the beta chain in human fibrin was used as an antigen to produce monoclonal antibodies that bind to fibrin even in the presence of human fibrinogen at the concentration found in plasma. As expected, the antifibrin activity was inhibited by the peptide antigen but not by a control heptapeptide. In a chicken ex vivo circulatory model for fibrin detection, intravenously administered monoclonal antibodies bound to human fibrin-coated disks placed in an extracorporeal chamber. These findings may lead to better methods for identifying deep vein and coronary artery thrombi.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hui, K Y -- Haber, E -- Matsueda, G R -- HL28015/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1129-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648524" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Monoclonal/*immunology
;
Antibody Specificity
;
Fibrin/*immunology
;
Fibrinogen/*immunology
;
Humans
;
Peptide Fragments/chemical synthesis/immunology
;
Polymers
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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