ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • *Ion Channel Gating  (1)
  • Antarctica; Antarctic Circumpolar Current; DSDP; Neodymium isotopes; ODP 744; sortable silt  (1)
Collection
Keywords
Publisher
Years
  • 1
    facet.materialart.
    Unknown
    Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-07
    Description: Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the mammalian brain. Here, we show by proteomic analysis that the majority of AMPARs in the rat brain are coassembled with two members of the cornichon family of transmembrane proteins, rather than with the TARPs. Coassembly with cornichon homologs 2 and 3 affects AMPARs in two ways: Cornichons increase surface expression of AMPARs, and they alter channel gating by markedly slowing deactivation and desensitization kinetics. These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwenk, Jochen -- Harmel, Nadine -- Zolles, Gerd -- Bildl, Wolfgang -- Kulik, Akos -- Heimrich, Bernd -- Chisaka, Osamu -- Jonas, Peter -- Schulte, Uwe -- Fakler, Bernd -- Klocker, Nikolaj -- New York, N.Y. -- Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Physiology II, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19265014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology/*metabolism ; Cell Membrane/metabolism ; Glutamic Acid/metabolism ; Immunohistochemistry ; *Ion Channel Gating ; Kinetics ; Membrane Proteins/chemistry/metabolism ; Mice ; Neurons/*metabolism ; Patch-Clamp Techniques ; Protein Subunits/chemistry/metabolism ; Proteomics ; Rats ; Receptors, AMPA/chemistry/*metabolism ; Signal Transduction ; Synapses/metabolism ; *Synaptic Transmission ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Sortable silt and neodymium isotope data from DSDP Site 29-278, Southern Emerald Basin (Southwest Pacific) and ODP Site 119-744 Southern Kerguelen Plateau (South Indian) (2021)
    PANGAEA
    Details
    Publication Date: 2024-02-16
    Description: The Antarctic Circumpolar Current (ACC) has a pivotal role in global climate through its strong influence on the global overturning circulation, ocean heat and CO~2~ uptake and storage. When and how the ACC reached its modern-like conditions (i.e., vigorous, and deep-reaching) after the opening and deepening of the Drake Passage and the Tasmanian Gateway remains highly controversial. We present mean sortable silt and neodymium isotope records from the Deep Sea Drilling Project (DSDP) Leg 29 Site 278 located in the southern Emerald Basin (56°33.42'S, 160°04.29'E, 3675 m water depth) and Ocean Drilling Program (ODP) Leg 119 located in the southern Kerguelen Plateau (61°34.66'S, 80°35.43'E, 2307 m water depth) spanning the last 31 million years. These records were used to determine the timing of the onset of diagnostic features of today's ACC: a modern-like deep-reaching strong flow, and homogenisation (i.e., common water mass signature) of Circumpolar Deep Water within the ACC. Grain size was measured using the laser microgranulometer Malvern mastersizer hydro 2000G. Neodymium isotopes from Site 29-278 were measured on a Nu Plasma multiple collector inductively coupled plasma mass spectrometer (MC-ICP-MS).Neodymium isotopes from Site 119-744 were measured on a Thermo Scientific Triton Plus Thermal Ionization Mass Spectrometer (TIMIS).
    Keywords: Antarctica; Antarctic Circumpolar Current; DSDP; Neodymium isotopes; ODP 744; sortable silt
    Type: Dataset
    Format: application/zip, 7 datasets
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...