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  • 1
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    Extensive diversity of Ig-superfamily proteins in the immune system of insects (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-08-20
    Description: The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam). Secreted protein isoforms of Dscam were detected in the hemolymph, and hemocyte-specific loss of Dscam impaired the efficiency of phagocytic uptake of bacteria, possibly due to reduced bacterial binding. Importantly, the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watson, Fiona L -- Puttmann-Holgado, Roland -- Thomas, Franziska -- Lamar, David L -- Hughes, Michael -- Kondo, Masahiro -- Rebel, Vivienne I -- Schmucker, Dietmar -- 1RO1-NS46747-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1874-8. Epub 2005 Aug 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, Dana Farber Cancer Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16109846" target="_blank"〉PubMed〈/a〉
    Keywords: *Alternative Splicing ; Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Brain/metabolism ; Cell Adhesion Molecules ; Cell Line ; Drosophila Proteins/chemistry/*genetics/*immunology/metabolism ; Drosophila melanogaster/*genetics/*immunology/metabolism ; Escherichia coli/immunology/metabolism ; Fat Body/metabolism ; Hemocytes/immunology/*metabolism ; Hemolymph/chemistry ; Immunity, Innate ; Immunoglobulins/chemistry ; Insects/chemistry/genetics ; Molecular Sequence Data ; Neurons/metabolism ; Oligonucleotide Array Sequence Analysis ; Phagocytosis ; Protein Isoforms/chemistry/genetics/metabolism ; Protein Structure, Tertiary ; RNA Interference ; Receptors, Immunologic/immunology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Cell-intrinsic requirement of Dscam1 isoform diversity for axon collateral formation (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-05-17
    Description: The isoform diversity of the Drosophila Dscam1 receptor is important for neuronal self-recognition and self-avoidance. A canonical model suggests that homophilic binding of identical Dscam1 receptor isoforms on sister dendrites ensures self-avoidance even when only a single isoform is expressed. We detected a cell-intrinsic function of Dscam1 that requires the coexpression of multiple isoforms. Manipulation of the Dscam1 isoform pool in single neurons caused severe disruption of collateral formation of mechanosensory axons. Changes in isoform abundance led to dominant dosage-sensitive inhibition of branching. We propose that the ratio of matching to nonmatching isoforms within a cell influences the Dscam1-mediated signaling strength, which in turn controls axon growth and growth cone sprouting. Cell-intrinsic use of surface receptor diversity may be of general importance in regulating axonal branching during brain wiring.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, Haihuai -- Kise, Yoshiaki -- Izadifar, Azadeh -- Urwyler, Olivier -- Ayaz, Derya -- Parthasarthy, Akhila -- Yan, Bing -- Erfurth, Maria-Luise -- Dascenco, Dan -- Schmucker, Dietmar -- 2R01NS046747-05A1/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2014 Jun 6;344(6188):1182-6. doi: 10.1126/science.1251852. Epub 2014 May 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuronal Wiring Laboratory, Vlaams Instituut voor Biotechnologie (VIB) Vesalius Research Center, 3000 Leuven, Belgium. Department of Oncology, School of Medicine, University of Leuven, 3000 Leuven, Belgium. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. ; Neuronal Wiring Laboratory, Vlaams Instituut voor Biotechnologie (VIB) Vesalius Research Center, 3000 Leuven, Belgium. Department of Oncology, School of Medicine, University of Leuven, 3000 Leuven, Belgium. ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. ; Neuronal Wiring Laboratory, Vlaams Instituut voor Biotechnologie (VIB) Vesalius Research Center, 3000 Leuven, Belgium. Department of Oncology, School of Medicine, University of Leuven, 3000 Leuven, Belgium. Institute of Biochemistry, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany. ; Neuronal Wiring Laboratory, Vlaams Instituut voor Biotechnologie (VIB) Vesalius Research Center, 3000 Leuven, Belgium. Department of Oncology, School of Medicine, University of Leuven, 3000 Leuven, Belgium. dietmar.schmucker@vib-kuleuven.be.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24831526" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Axons/*physiology ; Cell Adhesion Molecules/genetics/*physiology ; Drosophila Proteins/genetics/*physiology ; Drosophila melanogaster/genetics/*growth & development ; Gene Dosage ; Mechanotransduction, Cellular/genetics/physiology ; Protein Isoforms/genetics/*physiology ; RNA Interference
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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