Publication Date:
2004-09-18
Description:
Eosinophils are often dominant inflammatory cells present in the lungs of asthma patients. Nonetheless, the role of these leukocytes remains poorly understood. We have created a transgenic line of mice (PHIL) that are specifically devoid of eosinophils, but otherwise have a full complement of hematopoietically derived cells. Allergen challenge of PHIL mice demonstrated that eosinophils were required for pulmonary mucus accumulation and the airway hyperresponsiveness associated with asthma. The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, James J -- Dimina, Dawn -- Macias, MiMi P -- Ochkur, Sergei I -- McGarry, Michael P -- O'Neill, Katie R -- Protheroe, Cheryl -- Pero, Ralph -- Nguyen, Thanh -- Cormier, Stephania A -- Lenkiewicz, Elizabeth -- Colbert, Dana -- Rinaldi, Lisa -- Ackerman, Steven J -- Irvin, Charles G -- Lee, Nancy A -- AI025230/AI/NIAID NIH HHS/ -- AI033043/AI/NIAID NIH HHS/ -- AR08545/AR/NIAMS NIH HHS/ -- F32 AR008545/AR/NIAMS NIH HHS/ -- F32 AR008545-01/AR/NIAMS NIH HHS/ -- F32 AR008545-02/AR/NIAMS NIH HHS/ -- F32 AR008545-03/AR/NIAMS NIH HHS/ -- HL058723/HL/NHLBI NIH HHS/ -- HL065228/HL/NHLBI NIH HHS/ -- HL10105/HL/NHLBI NIH HHS/ -- HLEB67273/HL/NHLBI NIH HHS/ -- NCRR-COBRE P20RR1555/RR/NCRR NIH HHS/ -- P01-HL67004/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2004 Sep 17;305(5691):1773-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. jjlee@mayo.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15375267" target="_blank"〉PubMed〈/a〉
Keywords:
Allergens/immunology
;
Animals
;
Asthma/immunology/*pathology/*physiopathology
;
Diphtheria Toxin/genetics
;
Eosinophil Peroxidase
;
Eosinophils/*physiology
;
Gene Targeting
;
Leukocyte Count
;
Lung/immunology/*pathology/*physiopathology
;
Mice
;
Mice, Transgenic
;
Models, Animal
;
Mucus/secretion
;
Ovalbumin/immunology
;
Peptide Fragments/genetics
;
Peroxidases/genetics
;
Respiratory Hypersensitivity/immunology/pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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