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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):959-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10691568" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; *Acquired Immunodeficiency Syndrome ; *Animal Experimentation ; Animals ; Breeding ; Costs and Cost Analysis ; Housing, Animal ; India ; *Macaca mulatta ; National Institutes of Health (U.S.) ; *Research ; Research Support as Topic ; Simian Acquired Immunodeficiency Syndrome ; Specific Pathogen-Free Organisms ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2001-10-06
    Description: Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennacchio, L A -- Olivier, M -- Hubacek, J A -- Cohen, J C -- Cox, D R -- Fruchart, J C -- Krauss, R M -- Rubin, E M -- HL-18574/HL/NHLBI NIH HHS/ -- HL-53917/HL/NHLBI NIH HHS/ -- HL66681/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2001 Oct 5;294(5540):169-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11588264" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alleles ; Animals ; Apolipoprotein C-III ; Apolipoproteins/*genetics/*physiology ; Apolipoproteins A ; Apolipoproteins C/blood ; Chromosomes, Human, Pair 11 ; Cohort Studies ; Computational Biology ; Coronary Disease/etiology/genetics ; Expressed Sequence Tags ; Female ; Haplotypes ; Humans ; Linkage Disequilibrium ; Lipoproteins, VLDL/blood ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Multigene Family ; Open Reading Frames ; Polymorphism, Single Nucleotide ; Risk Factors ; Sequence Analysis, DNA ; Transgenes ; Triglycerides/*blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Nov 19;286(5444):1454-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610540" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*immunology ; *Animal Experimentation ; Animals ; Bioethics ; CD4 Lymphocyte Count ; *Disease Models, Animal ; Drug Evaluation, Preclinical ; HIV/*pathogenicity/physiology ; HIV Infections/immunology/*prevention & control/virology ; *Pan troglodytes ; Virulence ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1999-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):656-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10454914" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*immunology ; Animals ; Avipoxvirus/genetics/immunology ; Clinical Trials as Topic ; Drug Industry ; HIV Antibodies/*biosynthesis/immunology ; HIV Envelope Protein gp120/immunology ; HIV Infections/prevention & control ; Humans ; Immunization, Secondary ; T-Lymphocytes, Cytotoxic/*immunology ; Vaccines, DNA/immunology ; Vaccines, Synthetic/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1999-07-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Jul 2;285(5424):26-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10428695" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antiviral Agents/therapeutic use ; Drug Therapy, Combination ; Egypt/epidemiology ; *Hepacivirus/genetics/immunology ; *Hepatitis C/epidemiology/therapy/transmission/virology ; Hepatitis C, Chronic ; Humans ; Interferon-alpha/therapeutic use ; Patents as Topic ; Recombinant Proteins ; Replicon ; Ribavirin/therapeutic use ; Viral Hepatitis Vaccines ; Virus Cultivation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1999-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1250-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10084928" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/pharmacology/*therapeutic use ; Clinical Trials as Topic ; Collagen/pharmacology/*therapeutic use ; Endostatins ; Humans ; Mice ; Neoplasms, Experimental/blood supply/*drug therapy/pathology ; Neovascularization, Pathologic/*drug therapy ; Newspapers as Topic ; Peptide Fragments/pharmacology/*therapeutic use ; Recombinant Proteins/pharmacology/therapeutic use ; Reproducibility of Results
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1999-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Feb 19;283(5405):1090-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10075560" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; *Acquired Immunodeficiency Syndrome/prevention & control/virology ; *Animal Experimentation ; Animals ; Bioethics ; *Disease Models, Animal ; Drug Evaluation, Preclinical ; HIV/*pathogenicity ; Pan troglodytes/*virology ; Risk Assessment ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1999-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):772-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10049113" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/*transmission/virology ; Africa, Central ; Animals ; Ape Diseases/virology ; *Disease Reservoirs ; Gabon ; HIV-1/*classification/genetics/isolation & purification ; Humans ; Pan troglodytes/classification/*virology ; Simian Acquired Immunodeficiency Syndrome/*virology ; Simian Immunodeficiency Virus/*classification/genetics/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-09-09
    Description: Can contracting another disease help suppress HIV? Researchers report intriguing new findings suggesting that a disease called scrub typhus may offer novel leads to developing anti-HIV treatments and vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 2000 Aug 25;289(5483):1278.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10979849" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Bacterial/immunology ; Giant Cells ; HIV/immunology/pathogenicity/*physiology ; HIV Infections/*complications/immunology/*virology ; Humans ; Mice ; Orientia tsutsugamushi/immunology ; Scrub Typhus/*complications/immunology ; Thailand ; Viral Load
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-03-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 2001 Mar 2;291(5509):1686-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11263450" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/immunology ; Acquired Immunodeficiency Syndrome/immunology/*prevention & control ; Animals ; Clinical Trials as Topic ; Drug Industry ; Genetic Vectors ; HIV Antibodies/biosynthesis/*immunology ; Haplorhini ; Humans ; Immunity, Cellular ; Immunization, Secondary ; International Cooperation ; SAIDS Vaccines/immunology ; Simian Acquired Immunodeficiency Syndrome/immunology/prevention & control ; Simian Immunodeficiency Virus/genetics ; Vaccines, DNA/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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