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  • 1
    Publication Date: 2000-03-24
    Description: One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benos, P V -- Gatt, M K -- Ashburner, M -- Murphy, L -- Harris, D -- Barrell, B -- Ferraz, C -- Vidal, S -- Brun, C -- Demailles, J -- Cadieu, E -- Dreano, S -- Gloux, S -- Lelaure, V -- Mottier, S -- Galibert, F -- Borkova, D -- Minana, B -- Kafatos, F C -- Louis, C -- Siden-Kiamos, I -- Bolshakov, S -- Papagiannakis, G -- Spanos, L -- Cox, S -- Madueno, E -- de Pablos, B -- Modolell, J -- Peter, A -- Schottler, P -- Werner, M -- Mourkioti, F -- Beinert, N -- Dowe, G -- Schafer, U -- Jackle, H -- Bucheton, A -- Callister, D M -- Campbell, L A -- Darlamitsou, A -- Henderson, N S -- McMillan, P J -- Salles, C -- Tait, E A -- Valenti, P -- Saunder, R D -- Glover, D M -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2220-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Hall, Cambridge CB10 1SD, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10731137" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Banding ; Computational Biology ; Cosmids ; DNA Transposable Elements ; DNA, Satellite ; Drosophila melanogaster/*genetics ; Genes, Insect ; In Situ Hybridization ; Repetitive Sequences, Nucleic Acid ; Sequence Analysis, DNA ; X Chromosome/*genetics/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1980-02-08
    Description: Several dysgenic traits may occur within the Drosophila melanogaster species as a result of crosses between different strains. Crossing two mutually interacting categories, named inducer and reactive, may lead, among other abnormalities, to a specific kind of female sterility that has proved useful for investigating the genetic factors involved in the interaction. The reactive state appears to result from a cytoplasmic state ultimately controlled by a chromosomal polygenic system. The inducer character is determined by a chromosomal factor that exhibits all characteristics of a transposable element. Overall, the data contribute to clarification of mutator activities in D. melanogaster and open new opportunities to investigate unusual genetic mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bregliano, J C -- Picard, G -- Bucheton, A -- Pelisson, A -- Lavige, J M -- L'Heritier, P -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):606-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766221" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Animals, Laboratory/genetics ; Animals, Wild/genetics ; Cytoplasm/physiology ; Drosophila melanogaster/*genetics ; Ecology ; Female ; Genes, Regulator ; Hot Temperature ; Hybridization, Genetic ; Infertility, Female/genetics ; Mutation ; Oocytes/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
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