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  • 1
    Electronic Resource
    Electronic Resource
    New effects in low energy scattering of pµ atoms (1999)
    Springer
    Hyperfine interactions 119 (1999), S. 63-69 
    Details
    ISSN: 1572-9540
    Keywords: scattering ; muons ; muonic hydrogen ; solid hydrogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Strong solid state effects in low energy scattering of pµ atoms in solid hydrogen are reported and analyzed. Such effects have been observed in TRIUMF experiment E742 where muons are stopped in thin frozen (3 K) layers of hydrogen. Emission of low energy pµ atoms from the hydrogen layer into adjacent vacuum was much higher than expected, based on calculations which ignored the solid nature of hydrogen. Monte Carlo simulations, performed using the scattering cross-sections with solid state effects taken into account, show the important role of the coherent elastic Bragg scattering in the diffusion of pµ atoms. For pµ energies lower than the Bragg cut-off limit (∼2 meV) the total scattering cross-section falls by several orders of magnitude, the hydrogen target becomes transparent and the emission of cold pµ atoms takes place.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012602501617
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Scattering of muonic hydrogen atoms (1999)
    Springer
    Hyperfine interactions 119 (1999), S. 35-44 
    Details
    ISSN: 1572-9540
    Keywords: scattering ; muonic atom ; molecular formation rate ; time-of-flight ; Ramsauer–Townsend effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Our measurement compares the energy dependence of the scattering cross-sections of muonic deuterium and tritium on hydrogen molecules for collisions in the energy range 0.1–45 eV. A time-of-flight method was used to measure the scattering cross-section as a function of the muonic atom beam energy and shows clearly the Ramsauer–Townsend effect. The results are compared with theoretical calculations by using Monte Carlo simulations. The molecular pdµ and ptµ formation creates background processes. We measure the formation rates in solid hydrogen by detecting the 5.5 MeV (pdµ) and 19.8 MeV (ptµ) γ-rays emitted during the subsequent nuclear fusion processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012646316638
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  • 3
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    An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-10-23
    Description: Patients with abetalipoproteinemia, a disease caused by defects in the microsomal triglyceride transfer protein (MTP), do not produce apolipoprotein B-containing lipoproteins. It was hypothesized that small molecule inhibitors of MTP would prevent the assembly and secretion of these atherogenic lipoproteins. To test this hypothesis, two compounds identified in a high-throughput screen for MTP inhibitors were used to direct the synthesis of a highly potent MTP inhibitor. This molecule (compound 9) inhibited the production of lipoprotein particles in rodent models and normalized plasma lipoprotein levels in Watanabe-heritable hyperlipidemic (WHHL) rabbits, which are a model for human homozygous familial hypercholesterolemia. These results suggest that compound 9, or derivatives thereof, has potential applications for the therapeutic lowering of atherogenic lipoprotein levels in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wetterau, J R -- Gregg, R E -- Harrity, T W -- Arbeeny, C -- Cap, M -- Connolly, F -- Chu, C H -- George, R J -- Gordon, D A -- Jamil, H -- Jolibois, K G -- Kunselman, L K -- Lan, S J -- Maccagnan, T J -- Ricci, B -- Yan, M -- Young, D -- Chen, Y -- Fryszman, O M -- Logan, J V -- Musial, C L -- Poss, M A -- Robl, J A -- Simpkins, L M -- Slusarchyk, W A -- Sulsky, R -- Taunk, P -- Magnin, D R -- Tino, J A -- Lawrence, R M -- Dickson, J K Jr -- Biller, S A -- New York, N.Y. -- Science. 1998 Oct 23;282(5389):751-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Metabolic Diseases, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. Wetterau_John_R@msmail.bms.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9784135" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine Transaminase/blood ; Animals ; Apolipoproteins B/*blood ; Aspartate Aminotransferases/blood ; Carrier Proteins/*antagonists & inhibitors ; Cholesterol/*blood ; Cricetinae ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Design ; Drug Evaluation, Preclinical ; Fluorenes/chemistry/pharmacokinetics/*pharmacology ; Humans ; Hyperlipidemias/blood/drug therapy ; Hyperlipoproteinemia Type II/*blood/drug therapy ; Lipids/blood ; Lipoproteins/blood ; Liver/metabolism ; Mice ; Piperidines/chemistry/pharmacokinetics/*pharmacology ; Rabbits ; Rats ; Triglycerides/*blood/metabolism ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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