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  • 1
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    Obesity drug pipeline not so fat (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):849-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574616" target="_blank"〉PubMed〈/a〉
    Keywords: Agouti-Related Protein ; Animals ; Anti-Obesity Agents/adverse effects/pharmacology/*therapeutic use ; Appetite/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Ciliary Neurotrophic Factor/therapeutic use ; Clinical Trials as Topic ; Cyclobutanes/adverse effects/therapeutic use ; Energy Intake ; Ghrelin ; Humans ; Hunger/drug effects ; Intercellular Signaling Peptides and Proteins ; Lactones/adverse effects/therapeutic use ; Leptin/metabolism/therapeutic use ; Mice ; Nerve Tissue Proteins/adverse effects/therapeutic use ; Neurons/metabolism ; Neuropeptide Y/metabolism/pharmacology ; Obesity/*drug therapy/metabolism ; Peptide Fragments ; Peptide Hormones/metabolism/pharmacology ; Peptide YY/metabolism/pharmacology ; Phentermine/adverse effects/therapeutic use ; Proteins/metabolism ; Receptors, Corticotropin/metabolism ; Receptors, Melanocortin ; Weight Loss ; alpha-MSH/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Obesity. Enzyme blocker prompts mice to shed weight (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-05
    Description: A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Jun 30;288(5475):2299-300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10917820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/drug effects ; Appetite Depressants/*pharmacology ; Brain/metabolism ; Enzyme Inhibitors/*pharmacology ; Fasting ; Fatty Acid Synthases/*antagonists & inhibitors ; Humans ; Liver/drug effects/metabolism ; Malonyl Coenzyme A/metabolism ; Mice ; Neuropeptide Y/genetics/metabolism ; Obesity/*drug therapy ; RNA, Messenger/genetics/metabolism ; Weight Loss/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Obesity research. Tracing leptin's partners in regulating body weight (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Mar 10;287(5459):1738-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10755923" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/metabolism ; Animals ; Appetite/physiology ; *Body Weight ; Carrier Proteins/genetics/metabolism ; Humans ; Hypothalamic Hormones/genetics/physiology ; Hypothalamus/*physiology ; Leptin/genetics/metabolism/*physiology ; Melanins/genetics/physiology ; Muscles/metabolism ; Neuropeptide Y/genetics/physiology ; Neuropeptides/physiology ; Obesity/genetics/*physiopathology ; Pituitary Hormones/genetics/physiology ; Pro-Opiomelanocortin/genetics/physiology ; Proteins/genetics/physiology ; *Receptors, Cell Surface ; Receptors, Leptin ; *Repressor Proteins ; Suppressor of Cytokine Signaling Proteins ; *Transcription Factors ; alpha-MSH/genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Obesity research. Pot-bellied mice point to obesity enzyme (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2001 Dec 7;294(5549):2071-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11739926" target="_blank"〉PubMed〈/a〉
    Keywords: 11-beta-Hydroxysteroid Dehydrogenase Type 2 ; Abdomen ; Adipose Tissue/*enzymology/metabolism ; Animals ; Body Composition ; Diabetes Mellitus/enzymology/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Hydrocortisone/blood/*metabolism ; Hydroxysteroid Dehydrogenases/antagonists & inhibitors/genetics/*metabolism ; Hypoglycemic Agents/pharmacology ; Male ; Metabolic Syndrome X ; Mice ; Mice, Transgenic ; Obesity/*enzymology/genetics/metabolism ; Skin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Innate immunity. Ancient system gets new respect (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2001 Mar 16;291(5511):2068-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11256394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Infective Agents/chemistry/therapeutic use ; Antimicrobial Cationic Peptides/chemistry/*immunology/physiology/therapeutic use ; Bacterial Infections/drug therapy/prevention & control ; Cell Membrane/drug effects/metabolism ; Clinical Trials as Topic ; Defensins/chemistry/immunology/physiology/therapeutic use ; *Drosophila Proteins ; Humans ; *Immunity, Innate ; Membrane Glycoproteins/metabolism ; Mycoses/drug therapy ; Peptides/chemistry/*immunology/physiology/*therapeutic use ; Receptors, Cell Surface/metabolism ; Signal Transduction/drug effects ; Toll-Like Receptors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Gene defect linked to Rett syndrome (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10532886" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosomal Proteins, Non-Histone ; Chromosome Mapping ; DNA-Binding Proteins/*genetics ; Female ; *Gene Expression Regulation ; Humans ; Male ; Methyl-CpG-Binding Protein 2 ; Mice ; Mice, Knockout ; Mutation ; Repressor Proteins/*genetics ; Rett Syndrome/*genetics ; X Chromosome/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Repairing the genome's spelling mistakes (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):316-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10438292" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Crigler-Najjar Syndrome/therapy ; DNA/chemistry/metabolism ; *DNA Repair ; Genes, Plant ; *Genetic Engineering ; Genetic Therapy/*methods ; Humans ; Mutagenesis ; Nucleic Acid Hybridization ; Oligonucleotides/metabolism ; Plants/genetics ; RNA/chemistry/metabolism ; Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    New lead found to a possible "insulin pill" (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 May 7;284(5416):886.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10357667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascomycota/*metabolism ; CHO Cells ; Cricetinae ; Diabetes Mellitus, Type 2/*drug therapy ; Drug Evaluation, Preclinical ; Hypoglycemic Agents/chemistry/isolation & purification/metabolism/*therapeutic ; use ; Indoles/chemistry/isolation & purification/metabolism/*therapeutic use ; Insulin/metabolism/pharmacology ; Mice ; Mice, Mutant Strains ; Receptor, Insulin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Chlamydia protein linked to heart disease (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1238-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10084921" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoimmune Diseases/immunology/microbiology ; Bacterial Proteins/*immunology ; Chlamydia/*immunology/metabolism ; Chlamydia Infections/complications/immunology ; Heart/microbiology ; Humans ; Mice ; *Molecular Mimicry ; Myocarditis/immunology/*microbiology ; Myocardium/*immunology ; Myosins/*immunology ; Peptides/immunology ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Neurobiology. Trigger found for synapse formation (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-06
    Description: Until now, neurobiologists have had little luck in finding the matchmakers of nerve cell connections, called synapses, in the brain. In today's issue of Cell, researchers report that a single protein can apparently trigger synapse formation between brain neurons isolated from mice and grown in culture. If the finding is borne out in living animals, it could provide fresh insights into how the brain is wired during embryonic development and might eventually provide new ways to enhance or at least maintain synapse formation in the brains of patients suffering from neurodegenerative diseases such as Parkinson's or Alzheimer's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Jun 9;288(5472):1718-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10877681" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology ; Cell Adhesion Molecules, Neuronal ; Cells, Cultured ; Membrane Proteins/analysis/genetics/*metabolism ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/analysis/genetics/*metabolism ; Neurons/*physiology ; Synapses/*physiology ; Synaptic Membranes/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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