Publication Date:
2010-03-20
Description:
Advances in genome technology have facilitated a new understanding of the historical and genetic processes crucial to rapid phenotypic evolution under domestication. To understand the process of dog diversification better, we conducted an extensive genome-wide survey of more than 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf. Here we show that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data. Furthermore, we find a surprising correspondence between genetic and phenotypic/functional breed groupings but there are exceptions that suggest phenotypic diversification depended in part on the repeated crossing of individuals with novel phenotypes. Our results show that Middle Eastern wolves were a critical source of genome diversity, although interbreeding with local wolf populations clearly occurred elsewhere in the early history of specific lineages. More recently, the evolution of modern dog breeds seems to have been an iterative process that drew on a limited genetic toolkit to create remarkable phenotypic diversity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494089/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494089/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vonholdt, Bridgett M -- Pollinger, John P -- Lohmueller, Kirk E -- Han, Eunjung -- Parker, Heidi G -- Quignon, Pascale -- Degenhardt, Jeremiah D -- Boyko, Adam R -- Earl, Dent A -- Auton, Adam -- Reynolds, Andy -- Bryc, Kasia -- Brisbin, Abra -- Knowles, James C -- Mosher, Dana S -- Spady, Tyrone C -- Elkahloun, Abdel -- Geffen, Eli -- Pilot, Malgorzata -- Jedrzejewski, Wlodzimierz -- Greco, Claudia -- Randi, Ettore -- Bannasch, Danika -- Wilton, Alan -- Shearman, Jeremy -- Musiani, Marco -- Cargill, Michelle -- Jones, Paul G -- Qian, Zuwei -- Huang, Wei -- Ding, Zhao-Li -- Zhang, Ya-Ping -- Bustamante, Carlos D -- Ostrander, Elaine A -- Novembre, John -- Wayne, Robert K -- R01 GM083606/GM/NIGMS NIH HHS/ -- R01 GM083606-03/GM/NIGMS NIH HHS/ -- ZIC HG200365-01/Intramural NIH HHS/ -- ZIC HG200365-02/Intramural NIH HHS/ -- ZIC HG200365-03/Intramural NIH HHS/ -- England -- Nature. 2010 Apr 8;464(7290):898-902. doi: 10.1038/nature08837. Epub 2010 Mar 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, 621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20237475" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Domestic/classification/*genetics
;
Animals, Wild/classification/genetics
;
Breeding
;
Computational Biology
;
Dogs/classification/*genetics
;
Evolution, Molecular
;
Far East/ethnology
;
Genome/*genetics
;
Haplotypes/*genetics
;
Middle East/ethnology
;
Phenotype
;
Phylogeny
;
Polymorphism, Single Nucleotide/*genetics
;
Wolves/classification/genetics
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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