Publikationsdatum:
2000-08-01
Beschreibung:
Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful stimuli are normally absent or limited. Today, medical procedures for neonates with health risks can involve tissue injury and pain for which the long-term effects are unknown. To investigate the impact of neonatal tissue injury and pain on development of nociceptive neuronal circuitry, we used an animal model of persistent hind paw peripheral inflammation. We found that, as adults, these animals exhibited spinal neuronal circuits with increased input and segmental changes in nociceptive primary afferent axons and altered responses to sensory stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruda, M A -- Ling, Q D -- Hohmann, A G -- Peng, Y B -- Tachibana, T -- New York, N.Y. -- Science. 2000 Jul 28;289(5479):628-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cellular Neuroscience Section, Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA. maruda@dir.nidcr.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10915627" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Afferent Pathways
;
Animals
;
Animals, Newborn
;
Axons/physiology
;
Cell Count
;
Freund's Adjuvant
;
Ganglia, Spinal/cytology/physiology
;
Hindlimb/innervation
;
Inflammation/physiopathology
;
Male
;
Neurons, Afferent/cytology/*physiology
;
*Pain
;
Pain Measurement
;
Pain Threshold
;
Posterior Horn Cells/cytology/*physiology
;
Rats
;
Rats, Sprague-Dawley
;
Sciatic Nerve/cytology/physiology
;
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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