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  • 1
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    GABAergic pathway from zona incerta to neocortex: clarification (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-03-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, C S -- Nicolelis, M A -- Schneider, J S -- Chapin, J K Jr -- New York, N.Y. -- Science. 1991 Mar 8;251(4998):1162.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1706534" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Axonal Transport ; Cerebral Cortex/*anatomy & histology ; Diencephalon/*anatomy & histology ; Horseradish Peroxidase ; Mice ; Neurons/cytology ; Rats ; Thalamus/*anatomy & histology ; gamma-Aminobutyric Acid/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-05-08
    Beschreibung: A parkinsonian syndrome can be produced in nonhuman primates by administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Parkinsonian-like symptoms induced acutely by MPTP were ameliorated after treatment with GM1 ganglioside, a substance shown to have neurotrophic effects on the damaged dopamine system in rodents. Treatment with GM1 ganglioside also increased striatal dopamine and metabolite levels and enhanced the dopaminergic innervation of the striatum as demonstrated by tyrosine hydroxylase immunohistochemistry. These results suggest that GM1 ganglioside may hold promise as a therapeutic agent for the treatment of Parkinson's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneider, J S -- Pope, A -- Simpson, K -- Taggart, J -- Smith, M G -- DiStefano, L -- New York, N.Y. -- Science. 1992 May 8;256(5058):843-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Hahnemann University, School of Medicine, Philadelphia, PA 19102.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1350379" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; 3,4-Dihydroxyphenylacetic Acid/metabolism ; Animals ; Corpus Striatum/drug effects/*metabolism ; Dopamine/*metabolism ; G(M1) Ganglioside/*therapeutic use ; Homovanillic Acid/metabolism ; Immunohistochemistry ; Macaca fascicularis ; *Motor Activity/drug effects ; Parkinson Disease, Secondary/chemically induced/*drug therapy/metabolism ; Putamen/drug effects/metabolism ; Reference Values ; Saimiri ; Tyrosine 3-Monooxygenase/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    A major direct GABAergic pathway from zona incerta to neocortex (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-06-22
    Beschreibung: Retrograde fluorescent tracers were used to demonstrate a previously unknown but sizable direct gamma-aminobutyric acid (GABA)-containing neuronal pathway from the zona incerta to the neocortex in rats. This incertocortical pathway was found to project bilaterally to the entire neocortex and exhibited a rough corticotopic organization. Many of the zona incerta neurons projecting to the parietal and occipital cortices could also be immunohistochemically stained with antibodies to glutamic acid decarboxylase and GABA. Few of these neurons were immunoreactive to tyrosine hydroxylase antibodies, which identify dopamine-containing neurons. Injections in the frontal and entorhinal cortices labeled many neurons near or within the dopaminergic A13 subdivision of the zona incerta. In addition, the incertocortical system was found to be significantly larger during early postnatal (2 to 3 weeks) development. The projection pattern of this newly discovered pathway resembles that of the monoaminergic and cholinergic systems, arising from the brainstem and forebrain, suggesting possible similarities of function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, C S -- Nicolelis, M A -- Schneider, J S -- Chapin, J K -- AA 06965/AA/NIAAA NIH HHS/ -- KO2-AA 00089/AA/NIAAA NIH HHS/ -- NS 26722/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1990 Jun 22;248(4962):1553-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2360049" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cerebral Cortex/analysis/enzymology/*physiology ; Diencephalon/analysis/enzymology/*physiology ; Dopamine/analysis ; Glutamate Decarboxylase/analysis ; Immunohistochemistry ; Neural Pathways/physiology ; Neurons/analysis/enzymology/*physiology ; Rats ; gamma-Aminobutyric Acid/analysis/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1994-11-18
    Beschreibung: Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones, a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, MEF2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaushal, S -- Schneider, J W -- Nadal-Ginard, B -- Mahdavi, V -- New York, N.Y. -- Science. 1994 Nov 18;266(5188):1236-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973707" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Binding Sites ; Cell Differentiation ; Cell Line ; DNA/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; *Gene Expression Regulation ; Genes, Reporter ; Haplorhini ; Helix-Loop-Helix Motifs ; Humans ; MADS Domain Proteins ; MEF2 Transcription Factors ; Mice ; Molecular Sequence Data ; Muscle, Skeletal/*cytology/metabolism ; MyoD Protein/biosynthesis/*metabolism ; Myogenic Regulatory Factors ; Myogenin/biosynthesis/genetics/metabolism ; Transcription Factors/genetics/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1994-06-03
    Beschreibung: The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to re-enter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneider, J W -- Gu, W -- Zhu, L -- Mahdavi, V -- Nadal-Ginard, B -- New York, N.Y. -- Science. 1994 Jun 3;264(5164):1467-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8197461" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blood ; Cell Cycle ; Cell Differentiation ; Cell Line ; Culture Media ; Gene Expression ; Helix-Loop-Helix Motifs ; Humans ; Mice ; Muscles/*cytology/metabolism ; Myogenin/metabolism ; *Nuclear Proteins ; Proteins/genetics/*physiology ; Recombinant Fusion Proteins/metabolism ; Retinoblastoma Protein/genetics/*physiology ; Retinoblastoma-Like Protein p107 ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Selection effects and binary galaxy velocity differences (1990)
    In:  CASI
    Details
    Publikationsdatum: 2013-08-31
    Beschreibung: Measurements of the velocity differences (delta v's) in pairs of galaxies from large statistical samples have often been used to estimate the average masses of binary galaxies. A basic prediction of these models is that the delta v distribution ought to decline monotonically. However, some peculiar aspects of the kinematics have been uncovered, with an anomalous preference for delta v approx. equal to 72 km s(sup-1) appearing to be present in the data. The authors examine a large sample of binary galaxies with accurate redshift measurements and confirm that the distribution of delta v's appears to be non-monotonic with peaks at 0 and approx. 72 km s (exp -1). The authors suggest that the non-zero peak results from the isolation criteria employed in defining samples of binaries and that it indicates there are two populations of binary orbits contributing to the observed delta v distribution.
    Schlagwort(e): ASTROPHYSICS
    Materialart: NASA, Marshall Space Flight Center, Paired and Interacting Galaxies: International Astronomical Union Colloquium No. 124; p 485-490
    Format: application/pdf
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  • 7
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    Massive low surface brightness galaxies (1993)
    In:  CASI
    Details
    Publikationsdatum: 2013-08-31
    Beschreibung: A multi-wavelength study of an extreme type of galaxy which will assist us in our attempts to understand the formation and evolution of galaxies was completed. In particular, a subset of low surface brightness (bar-mu(sub B) is approximately greater than 25 mag arcsec(sup -2)), giant galaxies (LSBG's) which contain large amounts of atomic gas (M(HI) is approximately greater than 10(exp 10) solar mass), have blue optical diameters similar to those of giant spiral galaxies, but which do not seem to have prodigious amounts of ongoing star formation were observed. Our sample was drawn from the first and second Palomar Sky Surveys. This population of galaxies has been largely ignored because of selection effects which make it difficult to detect optically. The question of how these massive systems differ from the higher surface brightness 'normal' spiral galaxies is addressed. Using B and R surface photometry, in conjunction with H-alpha, HI, CO-12, and far-infrared data, an attempt is made to determine if these galaxies had an early epoch of star formation that has since faded, have ongoing star formation with an unusual interplanetary magnetic field (IMF), or are perhaps galaxies which have never efficiently formed stars due to a lack of molecular clouds.
    Schlagwort(e): ASTROPHYSICS
    Materialart: NASA. Ames Research Center, The Evolution of Galaxies and Their Environment; p 84-85
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  • 8
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    Luminosity function of quasars at large redshifts from grism surveys (1991)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: We have carried out a systematic search for emission-line objects through photometrically calibrated CCD grism surveys with the Palomar 200-inch telescope in transit mode, covering 62 square degrees. These surveys have yielded 141 quasars detected by their C IV or Ly-alpha emission in the redshift range 2.0 - 4.7. We use this sample and the known flux limits to derive the slope of the luminosity function and the space density above a given line luminosity, as a function of redshift. While space densities are approximately constant at redshifts 2.0 - 3.0, they are declining steeply for redshifts larger than 3.
    Schlagwort(e): ASTROPHYSICS
    Materialart: In: The space distribution of quasars; Proceedings of the Workshop, Victoria, Canada, June 3-5, 1991 (A93-28776 10-90); p. 109-114; Discussi
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  • 9
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    The HST Quasar Absorption-Line Key Project. 8: CCD imaging of Hubble Space Telescope quasar fields (1994)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: We present an analysis of CCD images of more than 100 quasars; many of the objects have been or will be observed in the Hubble Space Telescope (HST) Key Project Quasar Absorption-Line Survey. The data set consists of B, g, and i photometry of 117 quasars and deeper g (limiting magnitude of approximately equal 22) images of 101 quasar fields. Positions accurate to approximately equal 1 sec, measured with the Space Telescope Science Institute's Astrometric Support Program, are listed for all of the quasars in this study. Positions, magnitudes, and classifications of stars and galaxies located within approximately equal 100 sec of the quasars are given for all of the deep g data. The positions of the stars and galaxies relative to the quasar are accurate to approximately equal 0.5 sec. The results presented here can be used to prepare spectroscopic programs designed to obtain redshifts of galaxies in the fields of these quasars.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astronomical Society of the Pacific, Publications (ISSN 0004-6280); 106; 700; p. 646-669
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  • 10
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    Northern dwarf and low surface brightness galaxies. II - The Green Bank neutral hydrogen survey (1992)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-12
    Beschreibung: The paper reports neutral hydrogen observations of a large sample of dwarf and other low surface brightness galaxies. A detailed discussion and error analysis of the observations are presented, and spectra are displayed for 329 galaxies detected for the first time, or detected with substantially better signal-to-noise ratios than achieved previously. The positions on the sky of 667 galaxies meeting the present selection criteria north of delta = 38 deg are shown. The distribution of the redshifts of galaxies detected at Green Bank is illustrated. The Green Bank detections tapered off strongly below the median H I flux of 3.7 Jy km/s detected at Arecibo: only 12 percent of the Green Bank sample was detected with smaller fluxes.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal Supplement Series (ISSN 0067-0049); 81; 1 Ju
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