Publication Date:
1980-11-21
Description:
Exposure of pregnant rats to the anesthetic nitrous oxide on the ninth day of gestation causes fetal resorption, skeletal anomalies, and macroscopic lesions including encephalocele, anophthalmia, microphthalmia, and gastroschisis. The inert gas xenon, which has anesthetic properties similar to those of nitrous oxide, does not cause teratogenic effects under the same experimental conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, G A -- Nahrwold, M L -- Tait, A R -- Taylor-Busch, M -- Cohen, P J -- Beaudoin, A R -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):899-901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434002" target="_blank"〉PubMed〈/a〉
Keywords:
Anesthetics/*adverse effects
;
Animals
;
Female
;
Nitrous Oxide/*toxicity
;
Pregnancy
;
Rats
;
Structure-Activity Relationship
;
*Teratogens
;
Xenon/*toxicity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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