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  • 1
    Electronic Resource
    Electronic Resource
    Optimization of the quantitative analysis of the major cannabis metabolite (11-nor-9-COOH-Δ9-tetrahydrocannabinol) in urine by gas chromatography/mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 16 (1988), S. 367-372 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A gas chromatographic/mass spectrometric electron impact method is presented for the detection and quantification of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) in urine, for use in the confirmation of presumptive results obtained by other techniques. Four extraction procedures, two solid-liquid and two liquid-liquid, have been compared. A comparison of two trimethylsilylating methods demonstrates that the best results are obtained by the use of a mixture containing N-methyl-N-trimethylsilyl-trifluoroacetamide, trimethyliodosilane and dithioerithritol (100:0.2:1) v/v/w. The use of ketoprofen as a new internal standard for the quantification of THC-COOH has proved to be very effective. Both spiked samples and samples from cannabis users have been successfully analysed. It has also been demonstrated that the presence of other drugs of abuse in urine samples do not interfere with cannabis quantification by the method reported here.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200160172
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  • 2
    Electronic Resource
    Electronic Resource
    Detection and quantification of non-steroidal anti-inflammatory agents by gas chromatography/mass spectrometry: Diclofenac (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 16 (1988), S. 361-365 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A sensitive and reliable gas chromatography/mass spectrometric assay for diclofenac in plasma using selected ion monitoring is described. The procedure is based on the acidic extraction of diclofenac and ketoprofen (internal standard) with toluene. Both compounds are converted into their ethyl ester derivatives with ethanol containing 0.5% (v/v) sulphuric acid. No internal cyclization to indolone side product is produced in these conditions. The ions monitored are m/z 214 for diclofenac and m/z 209 for ketoprofen. The main recovery of diclofenac added to plasma has been estimated around 84.6% (120 ng ml-1, n = 4). The intra-assay and inter-assay variability were 1.9% and 10.3%, respectively. The sensitivity was lower than 2 ng ml-1. The applicability of the assays to study the bioavailability of two formulations in a multiple-dosage trial is described. The method has been used in more than 600 determinations without any interference.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200160171
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  • 3
    Electronic Resource
    Electronic Resource
    Detection of testosterone esters in human plasma (1995)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 30 (1995), S. 1393-1404 
    Details
    ISSN: 1076-5174
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The detection of testosterone misuse in sports is currently based on the urinary testosterone to epitestosterone ratio, although in some rare instances physiological or pathological conditions could compromise the application of this general criterion. The detection in the body of traces of the unchanged testosterone esters really ingested would offer unequivocal confirmation of testosterone administration. In this work, the detectability of testosterone esters in humans was studied. Liquid-liquid extraction of human blood plasma and appropriate derivatization of nine testosterone esters are described. Different acyl (trifluoroacetyl, pentafluoropropionyl and heptafluorobutyryl) and trimethylsilyl derivatives were studied. The trimethylsilyl derivatives appear to be the best for screenign purposes based on the characteristics of their mass spectra, with abundant molecular ions in the high-mass range. They also offered good conditions for tandem mass spectrometric analysis, needed to achieve the required sensitivity after oral administration of the drugs. The method was successful in the detection and determination of intramuscularly administered testosterone propionate and testosterone enanthate and orally ingested testosterone undecanoate.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jms.1190301004
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