ISSN:
0951-4198
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Physics
Notes:
Negative-ion fast-atom bombardment mass spectra of bile acids show prominent [M - H]- pseudomolecular ions, and few fragment ions. Collision-induced dissociation of such pseudomolecular ions gives charge-remote fragmentations which are useful in structural identifications. It has been shown that bile acids conjugated with taurine (2-aminoethanesulphonic acid) give more intense and informative collision-induced dissociation spectra than unconjugated bile acids. In this laboratory, a procedure for the aminosulphation of biological samples, for analysis by tandem mass spectrometry, has been developed. In the present study, a comparison has been made between the collision-induced dissociation spectra of a series of sulphated and glucuronidated bile acids and their 2-aminoethanesulphonic acid derivatives.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/rcm.1290080302
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