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  • 1
    Electronic Resource
    Electronic Resource
    Aromatic hydroxylation of ellipticine in rats: Lack of an NIH shift (1976)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 3 (1976), S. 335-339 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Metabolites of the antitumor agent, ellipticine (NSC 71795), are mainly secreted in rat bile as two conjugates of hydroxylated ellipticine. The possible involvement of an arene oxide intermediate prior to hydroxylation and conjugation has been studied using 7,9-dideutero-ellipticine and by determining the conservation of deuterium in the phenolic products. The deuterated drug was synthesized by acid catalyzed exchange and was characterized by nuclear magnetic resonance and high and low resolution mass spectrometry. Mass spectra of two conjugated metabolites from rat bile showed a mass ion at m/e 263 (singly deuterated hydroxylated ellipticine). There was no evidence for conservation of deuterium at the position of hydroxylation (m/e 264). These results indicate that the major pathway of metabolism for this cancer chemotherapeutic drug, prior to conjugation and excretion in rat bile, proceeds by aromatic hydroxylation apparently without involving an arene oxide/NIH shift mechanism.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200030612
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  • 2
    Electronic Resource
    Electronic Resource
    Raman and infrared spectra of NiI2 · 6H2O (1991)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 22 (1991), S. 397-401 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The polarized Raman spectra and infrared absorption spectra of NiI2 · 6H2O were measured in the 50-4000 cm-1 region at low temperatures. Deuterated samples were also studied and gave results which were useful for interpretation purposes. Satisfactory assignments of water internal and external modes and lattice vibrations were made. The vibrational analysis, on the basis of which the assignments were made, was related to the D34 factor group; however, the symmetry of the Raman-active bands, as deduced from polarized spectra, suggests that for water librations the C2h factor group provides a better basis for interpretation.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250220707
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  • 3
    Electronic Resource
    Electronic Resource
    Unambiguous structure determination of some pyrazolo [1,5-a]pyrimidine derivatives by multinuclear NMR spectroscopy (1992)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 30 (1992), S. 1117-1121 
    Details
    ISSN: 0749-1581
    Keywords: Pyrazolo[1,5-a]pyrimidines ; Structure determination ; Coupling constants ; 1H, 13C and 15N NMR spectra ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The condensation of 3(5)-aminopyrazole and 5-amino-3-phenylpyrazole with ethyl 2,4-dioxopentanoate and 2-ethoxymethylidene-3-oxobutyrate has been re-investigated. Contrary to previos reports, the former reaction gives rise to both regioisomeric pyrazolo [1,5-a]pyrimidines (5-carbethoxy-7-methyl-and 7-carbethoxy-5-methyl-), the structures of which were determined by 1H and 13C NMR spectroscopy. The 6-carbethoxy-7-methyl-regioisomer is shown to be the only product in the reaction of the same aminopyrazoles with 2-ethoxymethylidene-3-oxobutyrate; the regiochemical assignment was independently achieved by multimuclear (13C and 15N) NMR spectroscopy.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260301116
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