Publikationsdatum:
2008-02-15
Beschreibung:
Cooperation is central to many major transitions in evolution, including the emergence of eukaryotic cells, multicellularity and eusociality. Cooperation can be destroyed by the spread of cheater mutants that do not cooperate but gain the benefits of cooperation from others. However, cooperation can be preserved if cheaters are facultative, cheating others but cooperating among themselves. Several cheater mutants have been studied before, but no study has attempted a genome-scale investigation of the genetic opportunities for cheating. Here we describe such a screen in a social amoeba and show that cheating is multifaceted by revealing cheater mutations in well over 100 genes of diverse types. Many of these mutants cheat facultatively, producing more than their fair share of spores in chimaeras, but cooperating normally when clonal. These findings indicate that phenotypically stable cooperative systems may nevertheless harbour genetic conflicts. The opportunities for evolutionary moves and countermoves in such conflicts may select for the involvement of multiple pathways and numerous genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santorelli, Lorenzo A -- Thompson, Christopher R L -- Villegas, Elizabeth -- Svetz, Jessica -- Dinh, Christopher -- Parikh, Anup -- Sucgang, Richard -- Kuspa, Adam -- Strassmann, Joan E -- Queller, David C -- Shaulsky, Gad -- G0400103/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2008 Feb 28;451(7182):1107-10. doi: 10.1038/nature06558. Epub 2008 Feb 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas 77005, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18272966" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Amoeba/genetics/physiology
;
Animals
;
Cell Aggregation
;
Chimera/genetics/physiology
;
*Cooperative Behavior
;
Dictyostelium/cytology/*genetics/*physiology
;
Genes, Protozoan/genetics
;
Genome/genetics
;
Genomics
;
Mutation/*genetics
;
Myxococcus xanthus/genetics/physiology
;
Phenotype
;
*Social Behavior
;
Spores, Protozoan/genetics/physiology
Print ISSN:
0028-0836
Digitale ISSN:
1476-4687
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
Permalink
