Publication Date:
1988-06-03
Description:
In a study aimed at developing a vaccine against the asexual blood stages of Plasmodium falciparum, two T cell epitopes were identified within a nonpolymorphic region of gp190 of Plasmodium falciparum merozoites. The two epitopes, which were revealed by deletion analysis, stimulated human T cell clones. Peptides containing sequences of the epitopes stimulated the cloned T cells and peripheral blood mononuclear cells (PBMC) from malaria-infected individuals. Moreover, the T cell clones responded to 11 different Plasmodium falciparum isolates in culture, showing that the epitopes are recognized in native parasites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crisanti, A -- Muller, H M -- Hilbich, C -- Sinigaglia, F -- Matile, H -- McKay, M -- Scaife, J -- Beyreuther, K -- Bujard, H -- New York, N.Y. -- Science. 1988 Jun 3;240(4857):1324-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zentrum fur Molekulare Biologie, Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2453924" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Antigens, Protozoan/*immunology
;
Epitopes/analysis/*immunology
;
Humans
;
Molecular Sequence Data
;
Peptide Fragments/immunology
;
Plasmodium falciparum/*immunology
;
T-Lymphocytes/*immunology
;
T-Lymphocytes, Helper-Inducer/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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