Publication Date:
2003-02-08
Description:
Nuclear genes control plastid differentiation in response to developmental signals, environmental signals, and retrograde signals from plastids themselves. In return, plastids emit signals that are essential for proper expression of many nuclear photosynthetic genes. Accumulation of magnesium-protoporphyrin IX (Mg-Proto), an intermediate in chlorophyll biosynthesis, is a plastid signal that represses nuclear transcription through a signaling pathway that, in Arabidopsis, requires the GUN4 gene. GUN4 binds the product and substrate of Mg- chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. Thus, GUN4 participates in plastid-to-nucleus signaling by regulating Mg-Proto synthesis or trafficking.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larkin, Robert M -- Alonso, Jose M -- Ecker, Joseph R -- Chory, Joanne -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):902-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574634" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Amino Acid Substitution
;
Arabidopsis/*genetics/growth & development/metabolism
;
Arabidopsis Proteins/chemistry/*genetics/isolation & purification/*metabolism
;
Carrier Proteins/chemistry/*genetics/isolation & purification/*metabolism
;
Cell Nucleus/metabolism
;
Chlorophyll/*biosynthesis
;
Chloroplasts/*metabolism
;
Chromosome Mapping
;
Chromosomes, Plant
;
Cloning, Molecular
;
Cyanobacteria/enzymology/genetics/metabolism
;
Deuteroporphyrins/metabolism
;
Enzyme Activation
;
*Genes, Plant
;
Genes, Reporter
;
*Intracellular Signaling Peptides and Proteins
;
Lyases/chemistry/isolation & purification/metabolism
;
Magnesium/metabolism
;
Molecular Sequence Data
;
Mutation
;
Mutation, Missense
;
Protein Binding
;
Protein Subunits/metabolism
;
Protein Transport
;
Protoporphyrins/*metabolism
;
Recombinant Proteins/metabolism
;
*Signal Transduction
;
Thylakoids/chemistry/enzymology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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