Publication Date:
2009-07-31
Description:
The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727385/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727385/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finkel, Toren -- Deng, Chu-Xia -- Mostoslavsky, Raul -- R01 DK088190/DK/NIDDK NIH HHS/ -- R01 GM093072/GM/NIGMS NIH HHS/ -- Intramural NIH HHS/ -- England -- Nature. 2009 Jul 30;460(7255):587-91. doi: 10.1038/nature08197.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19641587" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/physiology
;
Animals
;
DNA Repair/physiology
;
Gene Expression Regulation, Enzymologic
;
Humans
;
Longevity/physiology
;
Sirtuins/metabolism/*physiology
;
Stress, Physiological/physiology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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