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  • 1
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    Spaceflight and the Mouse Eye: Results from Experiments on Shuttle Missions STS-133 and STS-135 (2013)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Vision alterations associated with globe flattening, chorodial folds and papilledema, shown in some crew members returning from long duration missions. Hypothesis: Ocular neuroanatomical changes observed in the VIIP syndrome are accompanied by retinal changes at the molecular and cellular level that may affect retinal health and physiology. Objective: Investigate evidence of ocular (retinal) changes associated with spaceflight: (1) histological markers of cellular death and damage (2) molecular markers of oxidative stress (3) gene expression markers of stress
    Keywords: Aerospace Medicine
    Type: JSC-CN-28096 , HRP IWS; Feb 12, 2012 - Feb 14, 2012; Galveston, TX; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 2
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    Spaceflight Effects and Molecular Responses in the Mouse Eye: Observations After Shuttle Mission STS-133 (2012)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Microgravity-induced cephalad fluid shift and radiation exposure are some of the stressors seen in space exploration. Ocular changes leading to visual impairment in astronauts are of occupational health relevance. Therefore, we analyzed the effects of space flight in the eyes of mice. Six mice were assigned to Flight (FLT), Animal enclosure Module (AEM), or vivarium (VIV) group, respectively. Mice were sacrificed at 1, 5 or 7 days after landing from space. One eye was used for histological and immunohistoche-mistry analysis and the other eye for gene expression profiling. 8-OHdG and caspase-3 immunoreactivity were increased in the retina in FLT samples at return(R+1) compared to AEM/VIV groups, and decreased at day 7 (R+7). beta-amyloid was seen in the nerve fibers at the post-laminar region of the optic nerve in the flight samples (R+7). In addition, oxidative and cellular stress response genes were upregulated in the retina of FLT samples upon landing, and decreased by R+7. According to the results, a reversible molecular damage may occur in the retina of mice exposed to spaceflight followed by protective cellular response.
    Keywords: Aerospace Medicine
    Type: JSC-CN-27453 , American Association of Ophthalmic (AAOOP); Nov 09, 2012; Chicago, IL; United States
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    NASA TECHNICAL REPORTS
  • 3
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    Species Specific Bacterial Spore Detection Using Lateral-Flow Immunoassay with DPA-Triggered Tb Luminescence (2003)
    In:  CASI
    Details
    Publication Date: 2019-07-12
    Description: A method of detecting bacterial spores incorporates (1) A method of lateral-flow immunoassay in combination with (2) A method based on the luminescence of Tb3+ ions to which molecules of dipicolinic acid (DPA) released from the spores have become bound. The present combination of lateral-flow immunoassay and DPA-triggered Tb luminescence was developed as a superior alternative to a prior lateral-flow immunoassay method in which detection involves the visual observation and/or measurement of red light scattered from colloidal gold nanoparticles. The advantage of the present combination method is that it affords both (1) High selectivity for spores of the species of bacteria that one seeks to detect (a characteristic of lateral-flow immunoassay in general) and (2) Detection sensitivity much greater (by virtue of the use of DPA-triggered Tb luminescence instead of gold nanoparticles) than that of the prior lateral-flow immunoassay method
    Keywords: Aerospace Medicine
    Type: NPO-30469 , NASA Tech Briefs, March 2003; 54-55
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Live/Dead Bacterial Spore Assay Using DPA-Triggered Tb Luminescence (2003)
    In:  CASI
    Details
    Publication Date: 2019-07-12
    Description: A method of measuring the fraction of bacterial spores in a sample that remain viable exploits DPA-triggered luminescence of Tb(3+) and is based partly on the same principles as those described earlier. Unlike prior methods for performing such live/dead assays of bacterial spores, this method does not involve counting colonies formed by cultivation (which can take days), or counting of spores under a microscope, and works whether or not bacterial spores are attached to other small particles (i.e., dust), and can be implemented on a time scale of about 20 minutes.
    Keywords: Aerospace Medicine
    Type: NPO-30444 , NASA Tech Briefs, March 2003; 55
    Format: application/pdf
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