ISSN:
1573-739X
Keywords:
Adverse effects
;
Calcium channels
;
Histamine H1 receptor blockaders
;
Metabolism
;
Receptors, histamine H1
;
Resolution
;
Stereoisomers
;
Synthesis
;
Terfenadine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Terfenadine was the first non-sedating histamine H1 receptor antagonist and one of the most frequently prescribed H1 antihistamines. Terfenadine has one asymmetric centre in the molecule and is currently used as a racemate. Different methods and approaches for obtaining pure enantiomers of terfenadine are summarized and discussed in the present paper. Studies on antihistamine activity of the enantiomers, their side-effects on the central nervous system, calcium channel affinity and metabolism are also reviewed and analysed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01880624
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