ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Admissibility of estimators  (1)
  • Alzheimer disease  (1)
  • 1995-1999  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of the Institute of Statistical Mathematics 50 (1998), S. 715-727 
    ISSN: 1572-9052
    Keywords: Admissibility of estimators ; Bayes estimators ; best equivariant estimator ; Langevin distribution ; mean direction vector ; Stein effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The circular normal distribution, CN(μ, κ), plays a role for angular data comparable to that of a normal distribution for linear data. We establish that for the curved and for the regular exponential family situations arising when κ is known, and unknown respectively, the MLE $$\widehat\mu$$ of the mean direction μ is the best equivariant estimator. These results are generalized for the MLE $$\widehat{\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } }$$ of the mean direction vector $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } = (\mu _1 , \ldots ,\mu _p )'$$ in the simultaneous estimation problem with independent CN(μ $$_i$$ , ϰ), i = 1,..., p, populations. We further observe that $$\widehat{\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } }$$ is admissible both when κ is known or unknown. Thus unlike the normal theory, Stein effect does not hold for the circular normal case. This result is generalized for the simultaneous estimation problem with directional data in q-dimensional hyperspheres following independent Langevin distributions, L( $$L(\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } _i ,\kappa ),i = 1, \ldots ,p$$ .
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1573-4919
    Keywords: cdk5 ; tau protein ; protein kinases ; Alzheimer disease ; paired helical filaments ; microtubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Tau protein from Alzheimer disease (AD) brain is hyperphosphorylated by both proline-dependent protein kinases (PDPKs) and non-PDPKs. It is presently unclear how PDPKs and non-PDPKs interact in tau hyperphosphorylation. Previously we have shown that non-PDPKs can positively modulate the activity of a PDPK (GSK-3) in tau phosphorylation (Singh et al. (1995) FEBS Lett. 358, 267-272). In this study we have investigated whether (A) non-PDPKs can also modulate the activity of the PDPK, cdk5, (B) a PDPK can modulate the activities of another PDPK, as well as non-PDPKs. We found that, like GSK-3, the activity of cdk5 is stimulated if tau were first prephosphorylated by any of several non-PDPKs (A-kinase, C-kinase, CK-1, CaM-kinase II). Prephosphorylation of tau by cdk5 stimulated both the rate and extent of a subsequent phosphorylation catalyzed by GSK-3. Under these conditions thr 231 phosphorylation was especially enhanced (9-fold). No significant stimulation of phosphorylation was obser ved when the order of these kinases was reversed (i.e. GSK-3 followed by cdk5). By contrast, prephosphorylation of tau by cdk5 served to inhibit subsequent phosphorylation catalyzed by C-kinase and CK-1, but not by A-kinase or CaM-kinase II. Our results suggest that in tau hyperphosphorylation in AD brain, cdk5-catalyzed phosphorylation may serve to up-regulate the activity of GSK-3 and down-regulate the activities of C-kinase and CK-1. (Mol Cell Biochem 167: 99-105, 1997)
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...