Publication Date:
2001-02-24
Description:
We obtain sterols from the animal and plant food that we eat. How these plant and animal sterols are absorbed, transported around the body, and excreted has been the subject of much investigation. In a Perspective, Allayee and colleagues discuss a new study (Berge et al.) that implicates two new ABC transporter proteins in the efflux of plant and animal sterols from gut epithelial cells into the gut lumen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allayee, H -- Laffitte, B A -- Lusis, A J -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1709-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA 90095, USA. hallayee@ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11186392" target="_blank"〉PubMed〈/a〉
Keywords:
ATP-Binding Cassette Transporters/chemistry/*genetics/metabolism
;
Adenosine Triphosphate/metabolism
;
Animals
;
Biological Transport, Active
;
Cholesterol/*metabolism
;
Cholesterol, Dietary/administration & dosage/metabolism/pharmacology
;
Chromosomes, Human, Pair 2
;
DNA-Binding Proteins
;
Gene Expression Regulation
;
Humans
;
*Intestinal Absorption
;
Intestines/metabolism
;
Lipid Metabolism, Inborn Errors/*genetics/metabolism
;
Lipoproteins/chemistry/*genetics/metabolism
;
Liver/metabolism
;
Mice
;
Oligonucleotide Array Sequence Analysis
;
Orphan Nuclear Receptors
;
Receptors, Cytoplasmic and Nuclear/metabolism
;
Sitosterols/*blood/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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