Publication Date:
1980-08-22
Description:
The growth of human cancer cells from lung, breast, and uterine tumors was selectively inhibited in a dose-dependent manner by ozone at 0.3 to 0.8 part per million of ozone in ambient air during 8 days of culture. Human lung diploid fibroblasts served as noncancerous control cells. The presence of ozone at 0.3 to 0.5 part per million inhibited cancer cell growth 40 and 60 percent, respectively. The noncancerous lung cells were unaffected at these levels. Exposure to ozone at 0.8 part per million inhibited cancer cell growth more than 90 percent and control cell growth less than 50 percent. Evidently, the mechanisms for defense against ozone damage are impaired in human cancer cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sweet, F -- Kao, M S -- Lee, S C -- Hagar, W L -- Sweet, W E -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):931-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403859" target="_blank"〉PubMed〈/a〉
Keywords:
Adenocarcinoma/drug therapy/pathology
;
Cell Division/*drug effects
;
Cell Survival
;
Cells, Cultured
;
Humans
;
Lung Neoplasms/drug therapy/pathology
;
Neoplasms, Experimental/drug therapy/*pathology
;
Ozone/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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