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  • 1
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    Attrition and translation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-10-25
    Description: The recently published NIH Roadmap proposes that public-sector science should place increased emphasis on the development of new therapeutics and diagnostics based on the fruits of fundamental research. Such "translational research" activities, traditionally the province of the private sector, have long been compromised by high rates of attrition (failure during the course of preclinical or clinical development of therapeutics). Attrition has led to growing financial costs, as well as opportunity costs. The new focus offers a way to reverse these trends, especially if the scientific community can improve on its ability to reconcile molecular genetic research with integrative organ- and organism-based research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duyk, Geoffrey -- New York, N.Y. -- Science. 2003 Oct 24;302(5645):603-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Exelixis Inc., 170 Harbor Way, South San Francisco, CA 94083, USA. duyk@exelixis.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14576424" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Biological Science Disciplines/education ; *Biomedical Research ; Biotechnology ; Chemistry, Pharmaceutical/economics ; Clinical Trials as Topic ; Costs and Cost Analysis ; Drug Industry/economics ; Guidelines as Topic ; Humans ; Molecular Biology/education ; *Pharmaceutical Preparations ; Pharmacology/education ; Physiology/education ; Private Sector ; Public Sector ; Research Support as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Human genetic map. Genome maps V. Wall chart (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buetow, K H -- Ludwigsen, S -- Scherpbier-Heddema, T -- Quillen, J -- Murray, J C -- Sheffield, V C -- Duyk, G M -- Weber, J L -- Weissenbach, J -- Gyapay, G -- New York, N.Y. -- Science. 1994 Sep 30;265(5181):2055-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8091228" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping ; Chromosomes, Human ; Genetic Markers ; *Genome, Human ; *Human Genome Project ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC) (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-30
    Description: In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identify genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project--a comprehensive, high-density genetic map.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, J C -- Buetow, K H -- Weber, J L -- Ludwigsen, S -- Scherpbier-Heddema, T -- Manion, F -- Quillen, J -- Sheffield, V C -- Sunden, S -- Duyk, G M -- New York, N.Y. -- Science. 1994 Sep 30;265(5181):2049-54.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, University of Iowa, Iowa City 52245.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8091227" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping ; Chromosomes, Human ; Databases, Factual ; Female ; Genetic Markers ; *Genome, Human ; Genotype ; *Human Genome Project ; Humans ; Male
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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