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Postischemic ATP levels predict hepatic function 24 hours following ischemia in the rat (1988)

Metzger, J. ; Lauterburg, B. H.

Springer

Cellular and molecular life sciences 44 (1988), S. 455-457

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ISSN: 1420-9071

Keywords: Liver ischemia ; hepatic function ; aminopyrine demethylation ; ATP

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Hepatic function was assessed by the aminopyrine breath test (ABT) in male Sprague Dawley rats 24 h after partial hepatic ischemia. ABT decreased progressively to 26.3 (p〈0.05) and 19.7% of dose (p〈0.05) after 90 and 120 min of ischemia, respectively. ABT at 24 h after injury was correlated to the concentration of ATP in the ischemic lobes 1 h after the onset of reperfusion (r2=0.971) but not to ALT activity in plasma at 1 h (r2=0.391). We conclude that postischemic ATP levels are a better index of subsequent hepatic function than ALT.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01940546

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