Publication Date:
1992-06-19
Description:
Because human immunodeficiency virus (HIV) can be transmitted as cell-free virus or as infected cells (cell-associated virus), vaccines must protect against infection by both viral forms. Vaccine-mediated protection of nonhuman primates against low doses of cell-free HIV-1, HIV-2, or simian immunodeficiency virus (SIV) has been demonstrated. It is now shown that multiple immunizations of chimpanzees with HIV-1 antigens protected against infection with cell-associated virus. Protection can persist for extended periods (one animal had not been exposed to viral antigens for 1 year before challenge). These results show that it is possible to elicit long-lasting protective immunity against cell-associated HIV-1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fultz, P N -- Nara, P -- Barre-Sinoussi, F -- Chaput, A -- Greenberg, M L -- Muchmore, E -- Kieny, M P -- Girard, M -- New York, N.Y. -- Science. 1992 Jun 19;256(5064):1687-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Alabama, Birmingham 35294.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1609280" target="_blank"〉PubMed〈/a〉
Keywords:
AIDS Vaccines
;
Animals
;
HIV Antigens/immunology/therapeutic use
;
HIV Infections/*prevention & control
;
HIV-1/*immunology
;
Immunity, Active
;
Immunization, Passive
;
Immunologic Memory
;
Leukocytes, Mononuclear/*immunology
;
Longitudinal Studies
;
Pan troglodytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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