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  • 1
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    Asbestos surface charge heterogeneity and biological effects (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-09-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Light, W G -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280676" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Asbestos ; Humans ; Occupational Diseases/chemically induced ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-06
    Beschreibung: Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonner, T -- O'Brien, S J -- Nash, W G -- Rapp, U R -- Morton, C C -- Leder, P -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):71-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691137" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/genetics ; Animals ; Chromosome Aberrations ; Chromosome Mapping ; *Chromosomes, Human, 1-3 ; *Chromosomes, Human, 4-5 ; Cricetinae ; Humans ; Hybrid Cells ; Kidney Neoplasms/genetics ; Lung Neoplasms/genetics ; Male ; Mice ; Nucleic Acid Hybridization ; *Oncogenes
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-01-13
    Beschreibung: T-cell growth factor (TCGF) or interleukin-2 (IL-2), an immunoregulatory lymphokine, is produced by lectin- or antigen-activated mature T lymphocytes and in a constitutive manner by certain T-cell lymphoma cell lines. By means of a molecular clone of human TCGF and DNA extracted from a panel of somatic cell hybrids (rodent cells X normal human lymphocytes), the TCGF structural gene was identified on human chromosome 4. In situ hybridization of the TCGF clone to human chromosomes resulted in significant labeling of the midportion of the long arm of chromosome 4, indicating that the TCGF gene was located at band q26-28. Genomic DNA from a panel of hybrids prepared with HUT-102 B2 cells was examined with the same molecular clone. In this clone of cells, which produces human T-cell leukemia virus, the TCGF gene was also located on chromosome 4 and was apparently not rearranged. The homologous TCGF locus in the domestic cat was assigned to chromosome B1 by using a somatic cell hybrid panel that segregates cat chromosomes. Linkage studies as well as high-resolution G-trypsin banding indicate that this feline chromosome is partially homologous to human chromosome 4.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seigel, L J -- Harper, M E -- Wong-Staal, F -- Gallo, R C -- Nash, W G -- O'Brien, S J -- New York, N.Y. -- Science. 1984 Jan 13;223(4632):175-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318318" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cats/*genetics ; Chromosome Banding ; Chromosome Mapping ; *Chromosomes ; *Chromosomes, Human, 4-5 ; Cloning, Molecular ; Deltaretrovirus ; *Genes ; Genetic Linkage ; Humans ; Hybrid Cells ; Interleukin-2/*genetics ; Nucleic Acid Hybridization
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Biologically active chorionic gonadotropin: synthesis by the human fetus (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: The kidney, and to a slight extent the liver, of human fetuses were found to synthesize and secrete the alpha subunit common to glycoprotein hormones. Fetal lung and muscle did not synthesize this protein. Since fetal kidney and liver were previously found to synthesize beta chorionic gonadotropin, their ability to synthesize bioactive chorionic gonadotropin was also determined. The newly synthesized hormone bound to mouse Leydig cells and elicited a biological response: namely, the synthesis of testosterone. These results suggest that the human fetus may participate in metabolic homeostasis during its development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGregor, W G -- Kuhn, R W -- Jaffe, R B -- HD08478/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):306-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682243" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Chorionic Gonadotropin/*biosynthesis ; Fetus/*metabolism ; Humans ; Kidney/embryology ; Leydig Cells/metabolism ; Liver/embryology ; Luteinizing Hormone/biosynthesis ; Male ; Mice ; Placenta/metabolism ; Testosterone/biosynthesis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-02-19
    Beschreibung: Nondeletion forms of hereditary persistence of fetal hemoglobin may result from regulatory disorders of globin gene expression. The defects in two such conditions were localized by demonstrating a tight genetic linkage between the disorders and polymorphic restriction endonuclease sites within the beta-like globin gene complex. In one instance, the defect probably occurred outside the region of DNA between the epsilon- and beta-globin genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Old, J M -- Ayyub, H -- Wood, W G -- Clegg, J B -- Weatherall, D J -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):981-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186021" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chromosome Deletion ; DNA Restriction Enzymes ; Female ; Fetal Hemoglobin/*genetics ; Genetic Linkage ; Globins/genetics ; Humans ; Male ; Pedigree ; Polymorphism, Genetic ; Thalassemia/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Acquisition of a memory skill (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-06-06
    Beschreibung: After more than 230 hours of practice in the laboratory, a subject was able to increase his memory span from 7 to 79 digits. His performance on other memory tests with digits equaled that of memory experts with lifelong training. With an appropriate mnemonic system, there is seemingly no limit to memory performance with practice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ericcson, K A -- Chase, W G -- Faloon, S -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1181-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375930" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Association Learning/physiology ; Humans ; Male ; Memory/*physiology ; Memory, Short-Term/physiology ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    Toxicant-disease-environment interactions associated with suppression of immune system, growth, and reproduction (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-06-01
    Beschreibung: The effects of marginal malnourishment , infections, and environmental chemicals on growth and reproductive success in Swiss-Webster white mice and wild deer mice were studied with fractional factorial designs. Interaction effects were discovered. For example, malnourished mice were more sensitive to virus exposure and environmental chemicals (a plant growth regulator or polychlorinated biphenyls). Since several commercial plant growth regulators also appear to suppress the immune system, these results cast doubt on the adequacy of current toxicity testing procedures in which factors are studied individually and not in combination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, W P -- Hinsdill, R -- Fairbrother, A -- Olson, L J -- Jaeger, J -- Yuill, T -- Bisgaard, S -- Hunter, W G -- Nolan, K -- 5-T32-ES07015/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):1014-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6426058" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Wild ; Chlormequat/adverse effects ; Cyclophosphamide/adverse effects ; Encephalomyelitis, Venezuelan Equine/physiopathology ; Environmental Exposure ; Female ; Food Supply ; Growth/*drug effects ; Humans ; Immunity/*drug effects ; Mice ; Nutrition Disorders/physiopathology ; Peromyscus ; Polychlorinated Biphenyls/adverse effects ; Pregnancy ; Reproduction/*drug effects ; Water Supply
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Data from tests of a R4 airfoil in the Langley 0.3-meter transonic cryogenic tunnel (1984)
    In:  CASI
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: Aerodynamic data for the DFVLR R4 airfoil are presented in both graphic and tabular form. The R4 was tested in the Langley 0.3-Meter Transonic Cryogenic Tunnel (TCT) at Mach number from 0.60 to 0.78 at angles of attack from -2.0 to 8.0 degrees. The airfoil was tested at Reynolds numbers of 4, 6, 10, 15, 30, and 40 million based on the 152.32 mm chord.
    Schlagwort(e): AERODYNAMICS
    Materialart: NASA-TM-85739 , NAS 1.15:85739
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 9
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    Two-dimensional aerodynamic characteristics of an airfoil designed for two (1981)
    In:  CASI
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: An airfoil designed for helicopter rotor application is investigated. The airfoil is designed to increase maximum normal force coefficient while maintaining favorable drag divergence and pitching moment characteristics. Two modifications are also tested. Maximum normal force coefficient varies from 1.14 to 0.90 at Mach numbers from about 0.35 to 0.65. Both modifications decreased drag coefficient at zero normal force coefficient for Mach numbers near drag divergence, but were less beneficial at a normal force coefficient of -0.2.
    Schlagwort(e): AERODYNAMICS
    Materialart: NASA-TP-1965 , L-14825 , NAS 1.60:1965 , AVRADCOM-TR-81-B-6
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 10
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    High Reynolds number tests of a Boeing BAC I airfoil in the Langley 0.3-meter transonic cryogenic tunnel (1982)
    In:  CASI
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: A wind tunnel investigation of an advanced-technology airfoil was conducted in the Langley 0.3-Meter Transonic Cryogenic Tunnel (TCT). This investigation represents the first in a series of NASA/U.X. industry two dimensional airfoil studies to be completed in the Advanced Technology Airfoil Test program. Test temperature was varied from ambient to about 100 K at pressures ranging from about 1.2 to 6.0 atm. Mach number was varied from about 0.40 to 0.80. These variables provided a Reynolds number (based on airfoil chord) range from about .0000044 to .00005. This investigation was specifically designed to: (1) test a Boeing advanced airfoil from low to flight-equivalent Reynolds numbers; (2) provide the industry participant (Boeing) with experience in cryogenic wind-tunnel model design and testing techniques; and (3) demonstrate the suitability of the 0.3-m TCT as an airfoil test facility. All the objectives of the cooperative test were met. Data are included which demonstrate the effects of fixed transition, Mach number, and Reynolds number on the aerodynamic characteristics of the airfoil. Also included are remarks on the model design, the model structural integrity, and the overall test experience.
    Schlagwort(e): AERODYNAMICS
    Materialart: NASA-TM-81922 , L-15011 , NAS 1.15:81922
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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