Publication Date:
2022-05-25
Description:
Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Cell Press for personal use, not for redistribution. The definitive version was published in Cell 169 (2017): 191-202, doi:10.1016/j.cell.2017.03.025.
Description:
RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the
genomic blueprint; however it is infrequently used among animals. Recent reports suggesting
increased levels of RNA editing in squids thus raise the question of their nature and effects in
these organisms. We here show that RNA editing is particularly common in behaviorally
sophisticated coleoid cephalopods, with tens of thousands of evolutionarily conserved sites.
Editing is enriched in the nervous system affecting molecules pertinent for excitability and
neuronal morphology. The genomic sequence flanking editing sites is highly conserved,
suggesting that the process confers a selective advantage. Due to the large number of sites, the
surrounding conservation greatly reduces the number of mutations and genomic polymorphisms
in protein coding regions. This trade-off between genome evolution and transcriptome plasticity
highlights the importance of RNA recoding as a strategy for diversifying proteins, particularly
those associated with neural function.
Description:
NLB was supported by a post-doctoral
scholarship from the Center for Nanoscience and Nanotechnology, Tel-Aviv University.
The research of RU is supported by the Israel Science Foundation (772/13). The research
of EYL was supported by the European Research Council (311257) and the Israel Science
Foundation (1380/14). The research of JJCR was supported by the National Institutes of
Health [1R0111223855, 1R01NS64259], the National Science Foundation (HRD-
1137725), and the Frank R. Lillie and Laura and Arthur Colwin Research Fellowships
from the Marine Biological Laboratory in Woods Hole. The work of JJCR and EE was
supported by grant No 094/2013 from the United States-Israel Binational Science
Foundation (BSF).
Description:
2018-04-06
Keywords:
Epitranscriptome
;
RNA modifications
;
RNA editing
;
ADAR
;
Neural plasticity
;
Cephalopods
;
Genome evolution
;
Proteome diversity
Repository Name:
Woods Hole Open Access Server
Type:
Preprint
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