ISSN:
1617-4623
Keywords:
Key wordsSchizosaccharomyces pombe
;
M-factor
;
Pheromone
;
ABC protein
;
Secretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract In the fission yeast Schizosaccharomyces pombe, cells of opposite mating type communicate via diffusible peptide pheromones prior to mating. We have cloned the S. pombe mam1 gene, which encodes a 1336-amino acid protein belonging to the ATP-binding cassette (ABC) superfamily. The mam1 gene is only expressed in M cells and the gene product is responsible for the secretion of the mating pheromone, M-factor, a nonapeptide that is S-farnesylated and carboxy-methylated on its C-terminal cysteine residue. The predicted Mam1 protein is highly homologous to mammalian multiple drug-resistance proteins and to the Saccharomyces cerevisiae STE6 gene product, which mediates export of a-factor mating pheromone. We show that STE6 can also mediate secretion of M-factor in S. pombe.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004380050493
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