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  • 1
    Electronic Resource
    Electronic Resource
    Phase II trial of 9-aminocamptothecin (NSC 603071) administered as a 120-hour continuous infusion weekly for three weeks in metastatic colorectal carcinoma (1998)
    Springer
    Investigational new drugs 16 (1998), S. 341-346 
    Details
    ISSN: 1573-0646
    Keywords: 9-AC ; 9-aminocamptothecin ; camptothecin ; colorectal cancer ; phase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract 9-Aminocamptothecin (9-AC) is a camptothecin derivative with broad antitumor activity in preclinical studies. Prior investigations suggested that prolonged maintenance of 9-AC lactone plasma concentrations above 10 nmol/l and frequent administration of the drug are important determinants of antitumor activity. Our phase II study, therefore, examined a 5-day continuous infusion of 9-AC weekly for 3 weeks in patients with advanced colorectal cancer. Eighteen patients previously untreated for metastatic disease received 480 μg/m2/day of 9-AC. No responses were observed in 17 evaluable patients. Severe toxicities included granulocytopenia, nausea, vomiting and diarrhea. The median absolute granulocyte count (AGC) nadir was 2,300/μl (range 0–9,000/μl) and occurred on day 10. Eight patients received an escalated dose of 600 μg/m2/day. The median AGC nadir at the escalated dose was 1,500/μl (range: 300–2,700/μl) and occurred on day 22. The median number of courses given was 2 (range: 1–8); and the median time to disease progression was 8 weeks (range: 1–40 weeks). 9-AC administered by this schedule lacked antitumor activity in patients with advanced colorectal carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006248700232
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    Paper (German National Licenses)
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  • 2
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    Vital involvement of a natural killer cell activation receptor in resistance to viral infection (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-08
    Description: Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, M G -- Dokun, A O -- Heusel, J W -- Smith, H R -- Beckman, D L -- Blattenberger, E A -- Dubbelde, C E -- Stone, L R -- Scalzo, A A -- Yokoyama, W M -- New York, N.Y. -- Science. 2001 May 4;292(5518):934-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11340207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/immunology ; *Antigens, Ly ; Crosses, Genetic ; Cytotoxicity, Immunologic ; Female ; Haplotypes ; Herpesviridae Infections/*immunology ; Histocompatibility Antigens Class I/immunology ; Humans ; *Immunity, Innate ; Killer Cells, Natural/*immunology ; Lectins, C-Type ; Ligands ; *Lymphocyte Activation ; Male ; Membrane Glycoproteins/genetics/*immunology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Muromegalovirus/*immunology ; Phenotype ; Receptors, Immunologic/*immunology ; Receptors, NK Cell Lectin-Like ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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