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  • 1
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    Interaction of convulsive ligands with benzodiazepine receptors (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: The gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is composed of distinct proteins embedded in the neuronal plasma membrane, is important for several effects of benzodiazepines, including protection afforded against convulsions. During structural modification of ethyl beta-carboline-3-carboxylate an agent was discovered which has high affinity for brain benzodiazepine receptors but which is a potent convulsant. Also in contrast to benzodiazepines, this type of benzodiazepine receptor ligand favors benzodiazepine receptors in the non-GABA-stimulated conformation, which may explain the convulsive properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Braestrup, C -- Schmiechen, R -- Neef, G -- Nielsen, M -- Petersen, E N -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1241-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281892" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Animals ; Carbolines/*metabolism ; Cerebellum/metabolism ; *Convulsants ; Indoles/*metabolism ; Ligands ; Macromolecular Substances ; Neural Inhibition ; Rats ; Receptors, Cell Surface/*metabolism ; Receptors, Drug/classification/*metabolism ; Receptors, GABA-A
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Bestimmung des Stroemungswiderstandes magnetischer Bakterien (1990)
    In:  50. Jahrestagung der Deutschen Geophysikalische Gesellschaft (Leoben, Austria 1990)
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    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/conferenceObject
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  • 3
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    Movement of magnetic bacteria in time-varying magnetic fields (1994)
    In:  Journal of Fluid Mechanics
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    Publication Date: 2020-02-12
    Description: The magnetic moment of individual living magnetic bacteria was determined by motion analysis in a time-dependent magnetic field. For this purpose we had to estimate the drag exerted on the moving bacterium by the surrounding liquid. First, the bacterium was approximated by an ellipsoid. In order to determine drag coefficients for more complicated (and realistic) forms, a model experiment was built. In this experiment enlarged models of bacteria were rotated in a viscous liquid and the torque acting upon them was measured. Computing algorithms were developed in order to calculate drag coefficients of magnetic bacteria and to simulate their motion in magnetic fields. The experimental and numerical determination of the drag coefficients agree within their error bounds. Besides the determination by motion analysis, the bacterial magnetic moment was also calculated from the number and size of magnetic particles contained in the bacterium as seen in an electron microscope. The results of both calculations agree well.
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 4
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    On the seismic discontinuities in the upper mantle. (1995)
    In:  Physics of the Earth and Planetary Interiors
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    Publication Date: 2020-02-12
    Description: Mode conversions and reflections at upper-mantle seismic discontinuities may be contained in earthquake seismograms as weak secondary phases that often become visible only after special signal processing techniques are applied to the data. To extract fully the information these secondary phases carry about the three-dimensional structure of the Earth, new observational and interpretational methods have to be developed. However, new sources of possible systematic errors may lead to conflicting results. Studies carried out by various research groups on the thickness of the upper-mantle transition zone, the sharpness of upper-mantle discontinuities and the global existence of a 520 km discontinuity are examples where such discrepancies did arise. Although there is a general consensus that the depths to the 410 km and 660 km discontinuities vary by a few tens of kilometres at most, the question of wither the depth variations of the 410 km and 660 km discontinuities are correlated or ant correlated is still unreso Similarly, different data sets and methods yielded different answers on the sharpness of the upper-mantle discontinuities at 410 km and 660 km depth. Finally, data apparently supporting the global existence of a seismic discontinuity at 520 km depth can be equally well explained by models that do not contain this discontinuity.
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 5
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    Receiver functions at the stations of the German Regional Seismic Network (GRSN) (1995)
    In:  Geophysical Journal International
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    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 6
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    Precursors to SS and structure of transition zone of the North-Western Pacific (1993)
    In:  Geophysical Research Letters
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    Publication Date: 2020-02-12
    Description: Abstract: In the records of the Graefenberg observatory and of a few other stations we have detected long-period SH reflections at the underside of mantle discontinuities. The bounce points of the reflections are located in the north-western margins of the Pacific. The data are used to evaluate S660S-S410S differential times which are directly related to the thickness of the layer between the two discontinuities. Most of the bounce points are in the area of the Japan and Kuril-Kamchatka subduction zones where a large-scale depression of the 660-km discontinuity was previously found and attributed to a cooling effect of subduction [Shearer & Masters, 1992]. According to our data the differential time in this region is 3 s less than in the IASP91 model. This anomaly suggest a thinning of the layer between the two discontinuities instead of thickening which is expected from depression of the lower discontinuity. Our analysis also indicates that there is a strong reflector in the study region a depth of 900 km.
    Keywords: 550 - Earth sciences
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  • 7
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    Sharpness of the mantle discontinuities (1993)
    In:  Geophysical Research Letters
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    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
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  • 8
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    Precursors to SS and structure of transition zone of the North-Western Pacific. (1993)
    In:  Geophysical Research Letters
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    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
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  • 9
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    The upper mantle discontinuities: correlated or anticorrelated? (1992)
    In:  Geophysical Research Letters
    Details
    Publication Date: 2020-02-12
    Description: The discontinuities in the Earth’s upper mantle at 410 km and 660 km are frequently considered as phase changes, which are exothermic and endothermic, respectively. From this follows that at laterally changing temperatures both discontinuities move in opposing vertical directions. That means they are negatively correlated. We attempt to test this hypothesis using travel times of seismic waves converted at both discontinuities underneath seismic stations. The broadband stations used are located in areas of high (e.g. western US) and low heat flow (e.g. Central Asia) (Sclater et al., 1980) . We observe a clear positive correlation of the conversion times of both discontinuities, which can however be explained with known lateral velocity changes above 410 km. From the scatter of our data we conclude that the limit of a possibly existing and negatively correlated topography of the two discontinuities is about 28 km. This is in contrast to recently claimed observations of about 35 km anticorrelated topography in the western Pacific (Revenaugh & Jordan, 1991; Stammler & Kind, 1992).
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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