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X-ray lasers as sources for resonance-fluorescence experiments (1994)

Koch, J. A. ; Lee, R. W. ; Nilsen, J. ; [et al.]

Springer

Applied physics 58 (1994), S. 7-11

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ISSN: 1432-0649

Keywords: 42.55.Vc ; 32.30.Rj ; 52.70

Source: Springer Online Journal Archives 1860-2000

Topics: Physics

Notes: Abstract We point out that existing Ne-like X-ray lasers have sufficient brightness to be used as pump sources in resonant pump-fluorescence experiments, and we discuss some of the potential benefits and limitations of such experiments. In preliminary experiments, we have measured the line overlap of the Ne-like yttrium X-ray laser near 155 Å with 4f−3d transitions in H-like Na and He-like Mg. These experiments used a high-resolution grating spectrometer, and calibrated the wavelength of the yttrium laser by comparison against lines of known wavelength. The results indicate that the wavelength of the yttrium laser is 154.985 ± 0.025 Å, a factor of 2–4 improvement in precision over previous calibrations. We find that the yttrium laser is ≈ 100 mÅ to the long-wavelength side of both the He-like Mg line and the H-like Na line, so that neither resonance is perfect; however, Stark broadening could improve the overlap in the latter scheme, and bulk Doppler shifting could improve both resonances. We also find a good resonance between the yttrium laser and an un-identified transition which we tentatively attribute to copper.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01081706

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Molecular species of epidermal growth factor carrying immunosuppressive activity (1984)

Koch, J. H. ; Fifis, T. ; Bender, V. J. ; [et al.]

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 25 (1984), S. 45-59

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ISSN: 0730-2312

Keywords: epidermal growth factor ; heterogeneity ; immunosuppressive activity ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: The suppression of antibody formation to sheep red cells in mice by partially purified fractions of mouse submaxillary gland [7] was shown to be caused by epidermal growth factor (EGF). Purification of EGF by the method of Savage and Cohen [11] resolved three components referred to as EGF a, EGF b, and EGF c. All three induced premature eye opening in neonatal mice, but only EGF a (identified as EGF1-53 ) had full immunosuppressive activity. EGF c was shown by micropeptide mapping of chymotryptic and thermolytic digests and aminoterminal analysis to differ from EGF a only by the presence of β-aspartyl instead of an asparaginyl residue. EGF b differed from EGF a in that it lacked the N-terminal asparagine. EGF shortened enzymatically at its carboxy terminal by two or five amino acids did not have any immunosuppressive activity. These findings-suggest that, in contrast to some other biological effects of EGF, intact amino and carboxy terminals are required for the expression of immunosuppressive activity.

Additional Material: 5 Ill.