ISSN:
1432-1041
Keywords:
Parkinsonism
;
5-hydroxyindoleacetic acid
;
cerebrospinal fluid
;
L-DOPA
;
homovanillic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary 5-Hydroxytryptamine (5-HT) turnover has been studied in eleven patients with Parkinson's disease before and during L-DOPA administration, using a test based on the fact that probenecid inhibits the active transport of acid monoamine metabolites, such as 5-hydroxyindoleacetic acid (5-HIAA), from cerebrospinal fluid to blood. A significant decrease in 5-HT turnover was observed during L-DOPA treatment, and possible mechanisms for it are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00565012
Permalink