ISSN:
1573-9171
Keywords:
4′-bromobenzocrowns, synthesis, metallation
;
4′-formylbenzocrown ethers
;
semicarbazones and oximes of 4′-formylbenzocrown ethers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A method for the synthesis of 4′-bromobenzodithia-15(18)-crown-5(6) and 4′-bromobenzodiaza-15 (18)-crown-5(6) by condensation of 3,4-di(2′-haloethoxy)bromobenzene with polyoxaalkanes containing terminal SH or NHMe groups was suggested. The method for the synthesis of formyl derivatives of benzocrowns containing N, S, and O heteroatoms in the macrocycle based on the metallation of appropriate bromo derivatives with BunLi followed by treatment of the resulting organolithium intermediates with DMF was developed. Oximes and semicarbazones of benzaldehydes containing a crown ether fragment were obtained, and their transformation into the original aldehydes by treatment with KNO2 in an acid medium was studied.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00696971
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