ISSN:
1420-9071
Keywords:
Cularines
;
isoquinoline alkaloids
;
3H-SCH 23 390
;
3H-raclopride
;
dopamine D-1/D-2 receptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Five natural cularines isolated from the aerial parts ofSarcocapnos crassifolia (Fumariaceae) and a cularioid isolated from the bark ofGuatteria ouregou (Annonaceae) were tested for their ability to displace3H-SCH 23 390 and3H-raclopride from their striatal binding sites. Celtisine, breoganine and cularidine were able to inhibit the binding at D-1 and D-2 dopaminergic sites at nanomolar concentrations. Other alkaloids were active at micromolar concentrations. These data suggest that the presence of an oxepine system in the isoquinoline skeleton could lead to compounds which would be very active and possibly selective at dopaminergic receptor sites.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923599
Permalink