ISSN:
1432-0649
Keywords:
87.50.Eg
;
35.50.Dq
;
42.65.Re
Source:
Springer Online Journal Archives 1860-2000
Topics:
Physics
Notes:
Abstract We report on a technique to improve fluorescence images of superficially growing tumors marked with photosensitizers. Exploiting the longer fluorescence decay times of porphyrin-based photosensitizers compared to average decay times of tissue autofluorescence, delayed detection of laser-induced fluorescence allows to suppress the autofluorescence background. The feasibility of delayed fluorescence imaging of tumors has been demonstrated in-vitro. It follows from an analysis of delayed fluorescence spectra that autofluorescence background falling into the photosensitizer fluorescence band can be reduced by up to one order of magnitude.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00332192
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