ISSN:
0170-2041
Keywords:
Amino acids
;
Ureas
;
Imidazolidin-2,4-diones
;
2-Isocyanatoalkanoic acids
;
Fmoc-2-trifluoromethyl amino acids
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
2-Trifluoromethyl-Substituted Amino Acids, 19. - 2-Trifluoromethyl α-Amino Acid Esters, Building Blocks for Trifluoromethyl-Substituted Ureas, Thioureas and Other Potential Biological Active StructuresThe preparative value of trifluoromethyl-substituted building blocks increases with the number of additional functionalities present. 2-Trifluoromethyl α-amino acid esters 2 represent readily available starting materials, excellently suited for the introduction of the biologically interesting trifluoromethyl group into a variety of classes of compounds, like ureas 4 and thioureas, acylureas 5 and acylthioureas 12, imidazolidin-2,4-diones 8 and imidazolidin-4-on-2-thiones 11 as well as 2-isocyanatoalkanoic acids 13. Via the latter Fmoc-2-trifluoromethyl α-amino acid 16a can be readily prepared.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199419940413
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