ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
2-Arylpropionic acids
;
Barbituric acids
;
Benzodiazepines
;
Cellulose tris(4-methylbenzoate) chiral stationary phase
;
Reversed-phase mode
;
Chiral recognition mechanisms
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A newly developed reversed-phase chiral stationary phase, cellulose tris(4-methylbenzoate), known as Chiralcel OJ-R, has been successfully applied to the direct resolution of the enantiomers of several nonsteroidal anti-inflammatory drugs belonging to the profen group. Among the five barbituric acids tested, the chiral resolution of mephobarbital is especially high. The Chiralcel OJ-R column also proved quite efficient for the enantiomeric resolution of a few representatives of the benzodiazepine group. Variations of mobile phase conditions based on acetonitrile and/or methanol were tested. The results obtained are briefly compared with separations performed using a Chiralcel OJ column under normalphase conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02292974
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