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  • 161-976B; 161-976E; 462; 465; 466; 468; 473; 476; 478; 479; 485; 490; 492; 493; Alboran Sea; Al Mansour Seamount; Cresta Genoveses; Dredge, chain bag; DRG_C; DRILL; Drilling/drill rig; Eastern Djibouti Bank; Ibn Batouta Western Seamount; Joides Resolution; Leg161; M51/1; M51/1_462DR; M51/1_465DR; M51/1_466DR; M51/1_468DR; M51/1_473DR; M51/1_476DR; M51/1_478DR; M51/1_479DR; M51/1_485DR; M51/1_490DR; M51/1_492DR; M51/1_493DR; Macizo Polacra; Meteor (1986); Northeastern Cabliers Bank; Northwestern Cabliers Bank; Ocean Drilling Program; ODP; Yusuf Ridge  (1)
  • nortriptyline  (1)
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  • 1
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    Geochemistry of Miocene Alborán Basin volcanism (2008)
    PANGAEA
    In:  Supplement to: Duggen, Svend; Hoernle, Kaj; Klügel, Andreas; Geldmacher, Jörg; Thirlwall, Matthew F; Hauff, Folkmar; Lowry, David; Oates, N (2008): Geochemical zonation of the Miocene Alborán Basin volcanism (westernmost Mediterranean): geodynamic implications. Contributions to Mineralogy and Petrology, 156(5), 557-593, https://doi.org/10.1007/s00410-008-0302-4
    Details
    Publication Date: 2024-02-02
    Description: We present new major and trace element and O-Sr-Nd-isotope data for igneous rocks from the western Mediterranean Alborán Sea, collected during the METEOR 51/1 cruise, and for high-grade schists and gneisses from the continental Alborán basement, drilled during the Ocean Drilling Programme (ODP Leg 161, Site 976). The geochemical data allow a detailed examination of crustal and mantle processes involved in the petrogenesis of the lavas and for the first time reveal a zonation of the Miocene Alborán Sea volcanism: (1) a keel-shaped area of LREE-depleted (mainly tholeiitic series) lavas in the central Alborán Sea, generated by high degrees of partial melting of a depleted mantle source and involving hydrous fluids from subducted marine sediments, that is surrounded by (2) a horseshoe-shaped zone with LREE-enriched (mainly calc-alkaline series) lavas subparallel to the arcuate Betic-Gibraltar-Rif mountain belt. We propose that the geochemical zonation of the Miocene Alborán Basin volcanism results from eastward subduction of Tethys oceanic lithosphere coupled with increasing lithospheric thickness between the central Alborán Sea and the continental margins of Iberia and Africa.
    Keywords: 161-976B; 161-976E; 462; 465; 466; 468; 473; 476; 478; 479; 485; 490; 492; 493; Alboran Sea; Al Mansour Seamount; Cresta Genoveses; Dredge, chain bag; DRG_C; DRILL; Drilling/drill rig; Eastern Djibouti Bank; Ibn Batouta Western Seamount; Joides Resolution; Leg161; M51/1; M51/1_462DR; M51/1_465DR; M51/1_466DR; M51/1_468DR; M51/1_473DR; M51/1_476DR; M51/1_478DR; M51/1_479DR; M51/1_485DR; M51/1_490DR; M51/1_492DR; M51/1_493DR; Macizo Polacra; Meteor (1986); Northeastern Cabliers Bank; Northwestern Cabliers Bank; Ocean Drilling Program; ODP; Yusuf Ridge
    Type: Dataset
    Format: application/zip, 7 datasets
    Location Call Number Expected Availability
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    DATA PANGAEA
  • 2
    Electronic Resource
    Electronic Resource
    Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 3 (1991), S. 14-18 
    Details
    ISSN: 0899-0042
    Keywords: debrisoquine ; nortriptyline ; desipramine ; polymorphism ; phenocopy ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1A single oral dose (50 mg) of quinidine significantly increased the debrisoquine metabolic ratio in six healthy volunteers. For four of the volunteers the metabolic ratio changed to that typical of the poor metaboliser (PM) phenotype.2The effect of quinidine in producing debrisoquine oxidation “poor metaboliser” phenocopies persisted for at least 3 days but had disappeared by 1 week.3The debrisoquine metabolic ratios for the same six subjects were not significantly altered by the oral administration of quinine (200 or 400 mg), the dia-stereoisomer of quinidine.4The plasma pharmacokinetic parameters of both nortriptyline and desipramine in healthy volunteers were all changed to those more typical of the debrisoquine PM phenotype following the concomitant administration of quinidine (50 mg).5It is concluded that quinidine, but not its diastereoisomer quinine, is a potent selective inhibitor of the in vivo oxidation of debrisoquine and can produce an artifactual PM phenocopy in persons who are phenotypically extensive metaboliser (EM) phenotype status. The clinical implications of this observation are discussed.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530030104
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