ISSN:
1436-5073
Keywords:
determination of morphine
;
potentiometry
;
fluoride electrode
;
kinetic analysis
;
illicit powders
;
1-fluoro-2,4-dinitrobenzene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A simple, accurate and selective method is described for the determination of morphine in illicit powders, based on monitoring the initial rate of fluoride ion liberation from the reaction of morphine with 1-fluoro-2,4-dinitrobenzene at pH 9 and 35 °C, using a solid-state fluoride ion-selective electrode. Under optimized reaction conditions, as little as 15 μg/ml of morphine is determined with an average recovery of 99.5% and a mean relative standard deviation of 1.2%. Determination of morphine in real illicit powders containing 6–18% morphine gives results comparing favorably with those obtained from isocratic reverse-phase high-performance liquid chromatography. No interferences are caused by many structurally related and associated compounds such as codeine, acetylcodeine, ethylmorphine, acetylmorphine and diacetylmorphine (heroin).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01244957
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