ISSN:
1434-4475
Keywords:
1-Pyrimidinyl-3-aryl-ureas
;
2,4,5-Trioxo-perhydro-imidazolyl-pyrimidine-2(H)-ones(thiones)
;
4,5-Substituted pyrimidine-2-one(thione)
;
Addition- and Cyclocondensation reactions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Zusammenfassung 1-Amino-5-benzoyl-4-phenyl-1H-pyrimidin-2-one(thione)1 addieren Arylisocyanate2 in guten Ausbeuten (60–95%) zu den Pyrimidinylharnstoff-Derivaten3, die ihrerseits mit Oxalylchlorid zu den Imidazolyl-pyrimidinen4 cyclisierbar sind. Versuche, die Amino-Verbindungen1 zu diazotieren, führen unter N2-Eliminierung zu den desaminierten Pyrimidinen6, die andererseits auch durch einfache Thermolyse der Methylenamino-pyrimidine7 entstehen.
Notes:
Summary 1-Amino-5-benzoyl-4-phenyl-1H-pyrimidine derivatives1 add arylisocyanates2 to give the N,N′-disubsituted ureas3 which can be cyclized by use of oxalyl dichloride to the imidazolyl-pyrimidinones(thiones)4. In addition,1 is transferred into the desaminated pyrimidines6 either by diazotation reaction or by thermolysis of the parental functionalized pyrimidine derivatives7.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00809772
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