ISSN:
1573-4986
Keywords:
carbohydrate antigens
;
Sd a -active oligosaccharides
;
β-4-N-acetylgalactosaminyltransferase
;
1 H-NMR spectroscopy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The tetrasaccharides GalNAcß1-4[NeuAcα2-3]Galß1-4Glc and GalNAcß1-4[NeuAcα2-3]Galß1-4GlcNAc were synthesised by enzymic transfer of GalNAc from UDP-GalNAc to 3′-sialyllactose (NeuAcα2-3Galß1-4Glc) and 3′-sialyl-N-acetyllactosamine (NeuAcα2-3Galß1-4GlcNAc). The structures of the products were established by methylation and1H-500 MHz NMR spectroscopy. In Sda serological tests the product formed with 3′-sialyl-N-acetyllactosamine was highly active whereas that formed with 3′-sialyllactose had only weak activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01047851
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