ISSN:
0170-2041
Keywords:
Anthracyclinones
;
Diels-Alder reactions, asymmetric
;
1,4-Anthraquinone
;
Isoprenyl ethers
;
1-Phenylethanol
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Diastereoselective Synthesis of Anthracyclinone Precursors[4 + 2] Cycloaddition of various dienes such as 1-acetoxy-1,3-butadienes 4a, b or 1-phenylethyloxy-1,3-butadienes 4c-g with 1,4-anthraquinones 3 affords tetracyclic precursors of anthracyclinone. Using the chiral substituted 1,3-butadienes 4 cycloadducts with d.e. 〉 98% are obtained. The high stereoselectivity is explained by π stacking.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930175
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