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  • 1
    ISSN: 0899-0042
    Keywords: optical resolution ; chiral HPLC ; chiral stationary phase ; 6-oxazolinylisoflavan ; circular dichroism ; antipicornavirus activity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Racemic 6-oxazolinylisoflavan, a highly effective inhibitor of rhinovirus serotype 1B in vitro, was resolved by high-performance liquid chromatography on a chiral stationary phase in order to study the activity of the enantiomers against picornaviruses. The absolute configuration of the two isomers was determined by circular dichroism curves. The antipicornavirus activity of each isomer, separately collected, was evaluated in vitro against human rhinovirus serotype 1B, enterovirus 71, echovirus 6, coxsackievirus B4, and poliovirus type 2 by means of the plaque reduction assay. Both enantiomers were inhibitors of picornavirus replication with the degree of their activity depending on virus and isomer tested. © 1993 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0899-0042
    Keywords: albendazole ; enantiomeric separation ; high performance liquid chromatography ; cellulose derived phase ; pharmacokinetic ; cysticercosis ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We present a method for the enantioselective analysis of albendazole sulfoxide (ABZSO) in plasma for application in clinical pharmacokinetic studies. ABZSO enantiomers were separated on a 5-μm Chiralcel OB-H® column (4.6 × 150 mm) using hexane:ethanol (93:7, v/v) as the mobile phase and fluorescence detection. ABZSO was extracted with chloroform:isopropanol (8:2, v/v) from 500-μl aliquots of acidified plasma, with full drug recovery. The proposed method presented quantitation limits of 20 ng/ml for (-)ABZSO and 50 ng/ml for (+)ABZSO and was linear up to a concentration of 5,000 ng/ml of each enantiomer. Chirality 9:722-726, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: In cystic fibrosis (CF), the most common mutation, delta F508 (a three-base-pair deletion) accounts for ca. 70% of mutations in the worldwide population. The majority of other mutations (more than 350 reported so far to the Genetic Analysis Consortium) have been detected in single cases, thus rendering quite cumbersome a molecular diagnostic approach for the identification of CF chromosomes. As an alternative, linkage analysis based on intragenic polymorphism can be useful for prenatal diagnosis and CF-carrier detection, provided that the heterozygosity of the allelic forms is very high. For this purpose, DNA microsatellites, consisting of two to epta nucleotide repeat clusters, displaying a high degree of polymorphism, are being increasingly used as markers in linkage studies. Two main allelic forms, one hexameric (111 bp) and one heptameric (115 bp), of a tetranucleotide (GATT) repeat polymorphism, at the junction of intron IVS6a and exon 6b, have been amplified by PCR technology. These two alleles can be separated in a 10-20%T polyacrylamide gradient gel and detected by ethidium bromide staining. As an alternate procedure, these two fragments are efficiently separated by capillary zone electrophoresis in a viscous solution of 6%T linear polyacrylamide and detected by their intrinsic absorbance at 254 nm.
    Additional Material: 2 Ill.
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 12 (1929), S. 989-990 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
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  • 5
    Publication Date: 2020-05-29
    Description: La caldera risorgente dei Campi Flegrei è, insieme ai vulcani Somma-Vesuvio, Ischia e Procida, uno degli elementi dominanti dell’assetto geologico e morfologico dell’area napoletana. Si tratta di un sistema vulcanico ancora attivo la cui persistente attività è testimoniata dall’ultima eruzione, avvenuta nel 1538, dall’intensa attività fumarolica e idrotermale che perdura da millenni e dai frequenti eventi bradisismici, con deformazione del suolo accompagnata da sismicità e variazioni delle caratteristiche chimico-fisiche dei fluidi emessi dalle fumarole. La caldera comprende la parte occidentale della città di Napoli e si estende nel Golfo di Pozzuoli. La caratteristica principale dell’attuale attività vulcanica della caldera è il movimento lento del suolo a carattere episodico e di grande ampiezza (bradisismo), accompagnato da un’intensa e superficiale attività sismica che si verifica in generale durante la fase di sollevamento......
    Description: Istituto Nazionale di Geofisica e Vulcanologia - Marina Militare Italiana
    Description: Published
    Description: 6A. Monitoraggio ambientale, sicurezza e territorio
    Description: open
    Keywords: Pozzuoli, bradisismo, prospezione geofisica, idrografia, oceanografia fisica ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: report
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  • 6
    Publication Date: 2017-04-04
    Description: Volcanic calderas are affected by unrest episodes usually dominated by hybrid magmatic-hydrothermal system dynamics. Unrest episodes can evolve to eruptions of variable intensity, up to Plinian. Campi Flegrei caldera (CFc) is a type-location for this kind of activity escalation. CFc offers unique opportunity to join volcanological information to a long record of geochemical parameters. This allows understanding the role that magmatic system plays on variations displayed by the hydrothermal system. We model uneruptive unrest episodes as driven by i) the shallow emplacement (~4 km depth) of one volatile-rich magma batch ascending from a deep (≥ 8 km) magmatic body of regional extent, ii) subsequent gas separation with degassing driven by crystallization and iii) fluxing from the deep magmatic body. Our model matches three decades of geochemical constraints from fumarole discharges, as well as data from melt inclusions of past CFc eruptions. Besides, magma physical properties demanded for modeled degassing conditions are in good agreement with existing geophysical data. Our results open new perspectives to the definition of unrest scenarios at highly-populated CFc, as well as other resurgent calderas (e.g., Orsi et al., This Assembly).
    Description: Published
    Description: Puerto de la Cruz,Tenerife (Canary Islands,Spain)
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: open
    Keywords: Geochemical Evidences ; Campi Flegrei ; 04. Solid Earth::04.04. Geology::04.04.11. Instruments and techniques ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Abstract
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  • 7
    Publication Date: 2017-04-04
    Description: Assessment of time and space relationships among magmatism, volcanism, and resurgence of mediumsize calderas is a necessary tool to formulate a general model for their dynamics which also permits to forecast their evolution. To define a general hypothesis for the Campi Flegrei caldera, in a persistent state of unrest, the Ischia and Pantelleria medium-size resurgent structures, in variable stages of evolution, have also been investigated. In particular some parameters such as the structural and volcanological evolution, with emphasis on resurgence dynamics and coeval volcanism, and the evolution, present state and role of the magmatic system in resurgence, have been defined. For the Campi Flegrei caldera, the data collected during unrest episodes have also been taken into account, together with those from past eruptions. They corroborate the hypothesis that the unrest episodes are transient short-term events within the long-term deformation related to caldera resurgence. The geometry of the short-term deformation is strictly related to the structural setting of the caldera. The sub-surface processes have been dominated by joint degassing of two magmatic bodies, at 3-4 and 8 (or more) km depth, with the shallower formed by magma ascending from the deeper body. Both bodies contribute to the hydrothermal system, but the shallow magma is fluxed by the continuous upstream of CO2-richer gas released by the deep body. The two-layer degassing magma allows explaining geochemical and petrological features of unrest and volcanism. The joined interpretation of geological, geodetic, and geochemical data on the three calderas is an innovative approach that adds a time-perspective on how resurgent calderas behave. The proposed general hypothesis will help in long- and short-term volcanic hazards assessment and will support Civil Defence Authorities in elaborating actions devoted to volcanic risk reduction.
    Description: Published
    Description: Puerto de la Cruz, Tenerife (Canary Islands,Spain)
    Description: open
    Keywords: the Case of Campi Flegrei ; Ischia and Pantelleria Structures ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.08. Risk::05.08.01. Environmental risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Abstract
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