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  • 1
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    FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (2013)
    Springer Nature
    Details
    Publication Date: 2013-04-05
    Description: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential Cell Death and Disease 4, e578 (April 2013). doi:10.1038/cddis.2013.109 Authors: S Romano, S Staibano, A Greco, A Brunetti, G Nappo, G Ilardi, R Martinelli, A Sorrentino, A Di Pace, M Mascolo, R Bisogni, M Scalvenzi, B Alfano & M F Romano
    Keywords: melanomametastasiscancer stem cellepithelial to mesenchymal transitionFKBP51
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Probabilistic hazard for seismically induced tsunamis: accuracy and feasibility of inundation maps (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2017-04-04
    Description: Probabilistic tsunami hazard analysis (PTHA) relies on computationally demanding numerical simulations of tsunami generation, propagation, and non-linear inundation on high-resolution topo-bathymetric models. Here we focus on tsunamis generated by co-seismic sea floor dis- placement, that is, on Seismic PTHA (SPTHA). A very large number of tsunami simulations are typically needed to incorporate in SPTHA the full expected variability of seismic sources (the aleatory uncertainty). We propose an approach for reducing their number. To this end, we (i) introduce a simplified event tree to achieve an effective and consistent exploration of the seismic source parameter space; (ii) use the computationally inexpensive linear approximation for tsunami propagation to construct a preliminary SPTHA that calculates the probability of maximum offshore tsunami wave height (H Max) at a given target site; (iii) apply a two-stage filtering procedure to these ‘linear’ SPTHA results, for selecting a reduced set of sources and (iv) calculate ‘non-linear’ probabilistic inundation maps at the target site, using only the selected sources. We find that the selection of the important sources needed for approximating probabilistic inundation maps can be obtained based on the offshore HMax values only. The filtering procedure is semi-automatic and can be easily repeated for any target sites. We describe and test the performances of our approach with a case study in the Mediterranean that considers potential subduction earthquakes on a section of the Hellenic Arc, three target sites on the coast of eastern Sicily and one site on the coast of southern Crete. The comparison between the filtered SPTHA results and those obtained for the full set of sources indicates that our approach allows for a 75–80 per cent reduction of the number of the numerical simulations needed, while preserving the accuracy of probabilistic inundation maps to a reasonable degree.
    Description: Published
    Description: 574-588
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: JCR Journal
    Description: restricted
    Keywords: Tsunami ; Hazard ; Probabilistic ; Subduction ; Mediterranean ; SPTHA ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.07. Tectonophysics::04.07.04. Plate boundaries, motion, and tectonics ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
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    Integrating geologic fault data into tsunami hazard studies (2013)
    Copernicus Publications
    Details
    Publication Date: 2017-04-04
    Description: We present the realization of a fault-source data set designed to become the starting point in regional-scale tsunami hazard studies. Our approach focuses on the parametric fault characterization in terms of geometry, kinematics, and assessment of activity rates, and includes a systematic classification in six justification levels of epistemic uncertainty related with the existence and behaviour of fault sources. We set up a case study in the central Mediterranean Sea, an area at the intersection of the European, African, and Aegean plates, characterized by a complex and debated tectonic structure and where several tsunamis occurred in the past. Using tsunami scenarios of maximum wave height due to crustal earthquakes (Mw=7) and subduction earthquakes (Mw=7 and Mw=8), we illustrate first-order consequences of critical choices in addressing the seismogenic and tsunamigenic potentials of fault sources. Although tsunamis generated by Mw=8 earthquakes predictably affect the entire basin, the impact of tsunamis generated by Mw=7 earthquakes on either crustal or subduction fault sources can still be strong at many locales. Such scenarios show how the relative location/orientation of faults with respect to target coastlines coupled with bathymetric features suggest avoiding the preselection of fault sources without addressing their possible impact onto hazard analysis results.
    Description: This work was supported by the EC-Research Framework programme FP7, Seismic Hazard Harmonization in Europe, Grant Agreement No. 226769 and the Flagship Project RITMARE – The Italian Research for the Sea – coordinated by the Italian National Research Council and funded by the Italian Ministry of Education, University and Research within the National Research Program 2011–2013.
    Description: Published
    Description: 1025-1050
    Description: 3.2. Tettonica attiva
    Description: 4.2. TTC - Modelli per la stima della pericolosità sismica a scala nazionale
    Description: JCR Journal
    Description: open
    Keywords: active fault ; tsunami ; tsunamigenic source ; earthquake ; PTHA ; hazard ; epistemic uncertainty ; tectonic moment rate ; 03. Hydrosphere::03.01. General::03.01.01. Analytical and numerical modeling ; 04. Solid Earth::04.04. Geology::04.04.01. Earthquake geology and paleoseismology ; 04. Solid Earth::04.04. Geology::04.04.04. Marine geology ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.07. Tectonophysics::04.07.04. Plate boundaries, motion, and tectonics ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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