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  • 1
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1134 (1992), S. 210-216 
    ISSN: 0167-4889
    Schlagwort(e): (Oxyuranus scutellatus scutellatus) ; Anionic channel ; Dorsal root ganglion ; Phospholipase A"2 ; Snake venom ; Whole-cell clamp
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Medizin , Physik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    ISSN: 1432-1424
    Schlagwort(e): Cerebellar granule neuron ; Heloderma horridum ; Helothermine ; Potassium current ; Patch clamp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Helothermine, a recently isolated toxin from the venom of the Mexican beaded lizard Heloderma horridum horridum was tested on K+ currents of newborn rat cerebellar granule cells. In whole-cell voltageclamp experiments, cerebellar granule neurons exhibited at least two different K+ current components: a first transient component which is similar to an I A-type current, is characterized by fast activating and inactivating kinetics and blocked by 4-aminopyridine; a second component which is characterized by noninactivating kinetics, is blocked by tetraetylammonium ions and resembles the classical delayed-rectifier current. When added to the standard external solution at concentrations ranging between 0.1 and 2 μm helothermine reduced the pharmacologically isolated I A-type current component in a voltage- and dose-dependent way, with a half-maximal inhibitory concentration (IC50) of 0.52 μm. A comparison between control and nelothermine-modified peak transient currents shows a slowdown of activation and inactivation kinetics. The delayed-rectifier component inhibition was concentration dependent (IC50 = 0.86 μm) but not voltage dependent. No frequency-or use-dependent block was observed on both K+ current types. Perfusing the cells with control solution resulted in quite a complete current recovery. We conclude that helothermine acts with different affinities on two types of K+ current present in central nervous system neurons.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2019-11-04
    Beschreibung: Deception Island - South Shetlands, Antarctica is site of active volcanism. Since 1988 field surveys have been carried out with the aim of seismic monitoring, and in 1994 a seismic array was set up near the site of the Spanish summer base in order to better constrain the source location and spectral properties of the seismic events related to the volcanic activity. The array was maintained during the Antarctic summer of 1995 and the last field survey was carried out in 1996. Data show the existence of three different groups (or families) of seismic events: 1) long period events, with a quasi-monochromatic spectral content (1-3 Hz peak frequency) and a duration of more than 50 s, often occurring in small swarms lasting from several minutes to some day; 2) volcanic tremor, with a spectral shape similar to the long period events but with a duration of several minutes (2-10); 3) hybrid events, with a waveform characterised by the presence of a high frequency initial phase, followed by a low frequency phase with characteristics similar to those of the long period events. The high frequency phase of the hybrid events was analysed using polarisation techniques, showing the presence of P waves. This phase is presumably located at short epicentral distances and shallow source depth. All the analysed seismic events show back-azimuths between 120 and 330 degrees from north (corresponding to zones of volcanic activity) showing no seismic activity in the middle of the caldera. Particle motion, Fourier spectral and spectrogram analysis show that the low frequency part of the three groups of the seismic signals have similar patterns. Moreover careful observations show that the high frequency phase which characterises the hybrid events is present in the long period and in the tremor events, even with lower signal to noise ratios. This evidence suggests that long period events are events in which the high frequency part is simply difficult to observe, due to a very shallow source and/or hypocentral distance higher than that of hybrids, while the tremor is composed of rapidly occurring hybrid events. We propose a possible interpretation for the three groups of seismic events. These may be generated by multiple pressure-steps due to the rapid phase change from liquid to vapour in a shallow aquifer which comes in contact with hot materials. The pressure change can put a crack in resonance or excite the generation of multiple surface waves modes in the shallow layered structure.
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): volcanic earthquakes ; tremor ; antartica ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Format: 5660911 bytes
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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