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  • 1
    Electronic Resource
    Electronic Resource
    Identifying human platelet glycoproteins IIb and IIIa by capillary electrophoresis (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 1468-1474 
    Details
    ISSN: 0173-0835
    Keywords: Glycoproteins ; Capillary electrophoresis ; Glanzmann's thrombasthenia ; Platelet membrane ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Glanzmann thrombasthenia (GT) is an inherited hemorrhagic defect due to a failure of the platelet membrane glycoprotein (GP) IIb-IIIa complex. Capillary electrophoresis (CE) analysis of solubilized platelet membranes from normal individuals showed the presence of two peaks with a migration time of 27 and 29 min, respectively. An excellent run-to-run and day-to-day reproducibility of the technique (〈 1% variation of the retention time) was documented. Using an automated Ferguson method, the apparent molecular masses were 100.0 kDa and 138.5 kDa, respectively. Immunoprecipitation with monoclonal antibodies anti-GP IIIa (B59.2.1) and anti-IIb (61.9.1.3) showed the two peaks as IIIa and IIb, respectively. Electropherograms of a GT young man showed the lack of both peaks. Less than 50% of each peak was present in his parents. Polyacrylamide gel electrophoresis (PAGE), immunoblotting, and flow cytometry analyses showed that GP IIb and IIIa were undetectable in the platelet membranes from the propositus, half of the normal amount being present in both parents. These findings indicate CE to be a rapid, sensitive and reliable tool to investigate patients with abnormalities of the GP IIb-IIIa complex.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150190842
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A 33 kDa protein band in enhanced during long-term adaptation of EUE cells to a hypertonic medium (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 9 (1991), S. 87-94 
    Details
    ISSN: 0263-6484
    Keywords: Hypertonic stress ; EUE cells ; SDS-PAGE ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A cell line derived from human embryonic epithelium (EUE cells) shows an enhanced expression of a 33 kDa protein when adapted to grow in a hypertonic medium containing 0·246 M NaCl (1·8 × the isotonic concentration). The maximum amount of this protein, followed by SDS-PAGE electrophoresis, was found after 4 days of adaptation; thereafter, the protein band remained fairly constant up to 30 days. When the cells were transferred back to a medium containing 0·137 M NaCl (isotonic medium), the protein pattern reverted to that of control cells. This protein is mainly localized in the cytosol, although a small part is associated with the 150 000 g pellet and needs detergents to be extracted. The molecular weight and the cellular location suggest a possible analogy with the so-called amphitropic proteins, that are known to interact with both the epidermal growth factor receptor and hydrophobic structures, such as the membrane phospholipids and the cytoskeletal components.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290090204
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  • 3
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    Coseismic and initial postseismic slip of the 2009 Mw 6.3 l’Aquila earthquake, Italy, from GPS measurements (2010)
    Details
    Publication Date: 2021-06-07
    Description: Here we report the preliminary results of GPS data inversions for coseismic and initial afterslip distributions of the Mw 6.3 2009 April 6 L’Aquila earthquake. Coseismic displacements of continuous and survey-style GPS sites, show that the earthquake ruptured a planar SW-dipping normal fault with ∼0.6 m average slip and an estimated moment of 3.9 × 1018 Nm. Geodetic data agree with the seismological and geological information pointing out the Paganica fault, as the causative structure of the main shock. The position of the hypocentre relative to the coseismic slip distribution supports the seismological evidence of southeastward rupture directivity. These results also point out that the main coseismic asperity probably ended downdip of the Paganica village at a depth of few kilometres in agreement with the small (1–10 cm) observed surface breaks. Time-dependent post-seismic displacements have been modelled with an exponential function. The average value of the estimated characteristic times for near-field sites in the hanging-wall of the fault is 23.9 ± 5.4 d. The comparison between coseismic slip and post-seismic displacements for the first 60 d after the main shock, shows that afterslip occurred at the edges of the main coseismic asperity with a maximum estimated slip of ∼25 cm and an equivalent seismic moment of 6.5 × 1017 Nm. The activation of the Paganica fault, spatially intermediate between the previously recognized main active fault systems, suggests that strain accumulation in the central Apennines may be simultaneously active on distinct parallel fault systems.
    Description: Published
    Description: 1539–1546
    Description: 1.1. TTC - Monitoraggio sismico del territorio nazionale
    Description: 1.9. Rete GPS nazionale
    Description: JCR Journal
    Description: restricted
    Keywords: satellite geodesy ; earthquake source observations ; Continental tectonics: extensional ; Europe ; 04. Solid Earth::04.03. Geodesy::04.03.01. Crustal deformations ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
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    Co-seismic displacements associated to the Molise (Southern Italy)earthquake sequence of October–November 2002 inferred from GPS measurements (2007)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The 2002 earthquake sequence of October 31 and November 1 (main shocks Mw=5.7) struck an area of the Molise region in Southern Italy. In this paper we analyzed the co-seismic deformation related to the Molise seismic sequence, inferred from GPS data collected before and after the earthquake, that ruptured a rather deep portion of crust releasing a moderate amount of seismic energy with no surface rupture. The GPS data have been reduced using two different processing strategies and softwares (Bernese and GIPSY) to have an increased control over the result accuracy, since the expected surface displacements induced by the Molise earthquake are in the order of the GPS reliability. The surface deformations obtained from the two approaches are statistically equivalent and show a displacement field consistent with the expected deformation mechanism and with no rupture at the surface. In order to relate this observation with the seismic source, an elastic modeling of fault dislocation rupture has been performed using seismological parameters as constraints to the model input and comparing calculated surface displacements with the observed ones. The sum of the seismic moments (8.9×1017 Nm) of the two main events have been used as a constraint for the size and amount of slip on the model fault while its geometry has been constrained using the focal mechanisms and aftershocks locations. Since the two main shocks exhibit the same fault parameters (strike of the plane, dip and co-seismic slip), we modelled a single square fault, size of 15 km×15 km, assumed to accommodate the whole rupture of both events of the seismic sequence. A vertical E–W trending fault (strike=266°) has been modeled, with a horizontal slip of 120 mm. Sensitivity tests have been performed to infer the slip distribution at depth. The comparison between GPS observations and displacement vectors predicted by the dislocation model is consistent with a source fault placed between 5 and 20 km of depth with a constant pure right-lateral strike-slip in agreement with fault slip distribution analyses using seismological information. The GPS strain field obtained doesn't require a geodetic moment release larger than the one inferred from the seismological information ruling out significant post-seismic deformation or geodetic deformation released at frequencies not detectable by seismic instruments. The Molise sequence has a critical seismotectonic significance because it occurred in an area where no historical seismicity or seismogenic faults are reported. The focal location of the sequence and the strike-slip kinematics of main shocks allow to distinguish it from the shallower and extensional seismicity of the southern Adriatic block from the northern one.
    Description: Published
    Description: 21-35
    Description: JCR Journal
    Description: reserved
    Keywords: GPS ; molise earthquake ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
    Format: 1535914 bytes
    Format: application/pdf
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  • 5
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    Very high rate (10 Hz) GPS seismology for moderate-magnitude earthquakes: The case of theMw6.3 L'Aquila (central Italy) event (2012)
    Details
    Publication Date: 2020-02-24
    Description: The 2009 April 6th Mw 6.3 L'Aquila destructive earthquake was successfully recorded by closely 23 spaced 10-Hz and 1-Hz recording GPS receivers and strong motion accelerometers located above or 24 close to the 50° dipping activated fault. We retrieved both static and dynamic displacements from 25 Very High-Rate GPS (VHRGPS) recordings by using Precise Point Positioning kinematic analysis. 26 We compared the GPS positions time series with the closest displacement time series obtained by 27 doubly-integrating strong motion data, first, to assess the GPS capability to detect the first seismic 28 arrivals (P waves) and, secondly, to evaluate the accelerometers capability to detect co-seismic 29 offsets up to ~45 s after the earthquake occurrence. By comparing seismic and VHRGPS frequency 30 contents, we inferred that GPS sampling rates greater than 2.5 Hz (i.e. 5 or 10 Hz) are required in 31 the near-field of moderate magnitude events to provide “alias-free” solutions of coseismic dynamic 32 displacements. Finally, we assessed the consistency of the dynamic VHRGPS results as a constraint 33 on the kinematic rupture history of the mainshock. These results suggested that the high-rate 34 sampling GPS sites in the near field can be as useful as strong motion station for earthquake source 35 studies.
    Description: Published
    Description: B02305
    Description: JCR Journal
    Description: open
    Keywords: 10 Hz GPS seismology ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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