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  • 1
    Electronic Resource
    Electronic Resource
    Identifying human platelet glycoproteins IIb and IIIa by capillary electrophoresis (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 1468-1474 
    Details
    ISSN: 0173-0835
    Keywords: Glycoproteins ; Capillary electrophoresis ; Glanzmann's thrombasthenia ; Platelet membrane ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Glanzmann thrombasthenia (GT) is an inherited hemorrhagic defect due to a failure of the platelet membrane glycoprotein (GP) IIb-IIIa complex. Capillary electrophoresis (CE) analysis of solubilized platelet membranes from normal individuals showed the presence of two peaks with a migration time of 27 and 29 min, respectively. An excellent run-to-run and day-to-day reproducibility of the technique (〈 1% variation of the retention time) was documented. Using an automated Ferguson method, the apparent molecular masses were 100.0 kDa and 138.5 kDa, respectively. Immunoprecipitation with monoclonal antibodies anti-GP IIIa (B59.2.1) and anti-IIb (61.9.1.3) showed the two peaks as IIIa and IIb, respectively. Electropherograms of a GT young man showed the lack of both peaks. Less than 50% of each peak was present in his parents. Polyacrylamide gel electrophoresis (PAGE), immunoblotting, and flow cytometry analyses showed that GP IIb and IIIa were undetectable in the platelet membranes from the propositus, half of the normal amount being present in both parents. These findings indicate CE to be a rapid, sensitive and reliable tool to investigate patients with abnormalities of the GP IIb-IIIa complex.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150190842
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A 33 kDa protein band in enhanced during long-term adaptation of EUE cells to a hypertonic medium (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 9 (1991), S. 87-94 
    Details
    ISSN: 0263-6484
    Keywords: Hypertonic stress ; EUE cells ; SDS-PAGE ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A cell line derived from human embryonic epithelium (EUE cells) shows an enhanced expression of a 33 kDa protein when adapted to grow in a hypertonic medium containing 0·246 M NaCl (1·8 × the isotonic concentration). The maximum amount of this protein, followed by SDS-PAGE electrophoresis, was found after 4 days of adaptation; thereafter, the protein band remained fairly constant up to 30 days. When the cells were transferred back to a medium containing 0·137 M NaCl (isotonic medium), the protein pattern reverted to that of control cells. This protein is mainly localized in the cytosol, although a small part is associated with the 150 000 g pellet and needs detergents to be extracted. The molecular weight and the cellular location suggest a possible analogy with the so-called amphitropic proteins, that are known to interact with both the epidermal growth factor receptor and hydrophobic structures, such as the membrane phospholipids and the cytoskeletal components.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290090204
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  • 3
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    Coseismic and initial postseismic slip of the 2009 Mw 6.3 l’Aquila earthquake, Italy, from GPS measurements (2010)
    Details
    Publication Date: 2021-06-07
    Description: Here we report the preliminary results of GPS data inversions for coseismic and initial afterslip distributions of the Mw 6.3 2009 April 6 L’Aquila earthquake. Coseismic displacements of continuous and survey-style GPS sites, show that the earthquake ruptured a planar SW-dipping normal fault with ∼0.6 m average slip and an estimated moment of 3.9 × 1018 Nm. Geodetic data agree with the seismological and geological information pointing out the Paganica fault, as the causative structure of the main shock. The position of the hypocentre relative to the coseismic slip distribution supports the seismological evidence of southeastward rupture directivity. These results also point out that the main coseismic asperity probably ended downdip of the Paganica village at a depth of few kilometres in agreement with the small (1–10 cm) observed surface breaks. Time-dependent post-seismic displacements have been modelled with an exponential function. The average value of the estimated characteristic times for near-field sites in the hanging-wall of the fault is 23.9 ± 5.4 d. The comparison between coseismic slip and post-seismic displacements for the first 60 d after the main shock, shows that afterslip occurred at the edges of the main coseismic asperity with a maximum estimated slip of ∼25 cm and an equivalent seismic moment of 6.5 × 1017 Nm. The activation of the Paganica fault, spatially intermediate between the previously recognized main active fault systems, suggests that strain accumulation in the central Apennines may be simultaneously active on distinct parallel fault systems.
    Description: Published
    Description: 1539–1546
    Description: 1.1. TTC - Monitoraggio sismico del territorio nazionale
    Description: 1.9. Rete GPS nazionale
    Description: JCR Journal
    Description: restricted
    Keywords: satellite geodesy ; earthquake source observations ; Continental tectonics: extensional ; Europe ; 04. Solid Earth::04.03. Geodesy::04.03.01. Crustal deformations ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
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    Coseismic deformation and source modeling of the May 2012 Emilia (Northern Italy) earthquakes (2013)
    Seismological Society of America
    Details
    Publication Date: 2017-04-04
    Description: On May 20th, 2012, an ML 5.9 earthquake (Table 1) occurred near the town of Finale Emilia, in the Central Po Plain, Northern Italy (Figure 1). The mainshock caused 7 casualties and the collapse of several historical buildings and industrial sheds. The earthquake sequence continued with diminishing aftershock magnitudes until May 29th, when an ML 5.8 earthquake occurred near the town of Mirandola, ~12 km WSW of the mainshock (Scognamiglio et al., 2012). This second mainshock started a new aftershock sequence in this area, and increased structural damage and collapses, causing 19 more casualties and increasing to 15.000 the number of evacuees. Shortly after the first mainshock, the Department of Civil Protection (DPC) activated the Italian Space Agency (ASI), which provided post-seismic SAR Interferometry data coverage with all 4 COSMO-SkyMed SAR satellites. Within the next two weeks, several SAR Interferometry (InSAR) image pairs were processed by the INGV-SIGRIS system (Salvi et al., 2012), to generate displacement maps and preliminary source models for the emergency management. These results included continuous GPS site displacement data, from private and public sources, located in and around the epicentral area. In this paper we present the results of the geodetic data modeling, identifying two main fault planes for the Emilia seismic sequence and computing the corresponding slip distributions. We discuss the implication of this seismic sequence on the activity of the frontal part of the Northern Apennine accretionary wedge by comparing the co-seismic data with the long term (geological) and present day (GPS) velocity fields.
    Description: Published
    Description: 645-655
    Description: 1.1. TTC - Monitoraggio sismico del territorio nazionale
    Description: 1.9. Rete GPS nazionale
    Description: 1.10. TTC - Telerilevamento
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: restricted
    Keywords: Earthquake ; CFF analysis ; Tectonic ; geodynamic ; Seismic source ; Northern apennine (Italy) ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.03. Geodesy::04.03.07. Satellite geodesy ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 05. General::05.01. Computational geophysics::05.01.01. Data processing ; 05. General::05.02. Data dissemination::05.02.02. Seismological data
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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